Metabolism

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Catalog No.
Product Name
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Product Citation
  1. Angiotensin 1/2 + A (2 - 8), potent endogenous vasoconstrictor peptide; derivative of angiotensin (Ang) II.
  2. BNP (1-32), human is a brain natriuretic peptide secreted by the human heart in response to cardiac volume or pressure.
  3. Renin inhibitor

    VTP-27999 2,2,2-trifluoroacetate is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases.
  4. Enkephalin-degrading and ACE inhibitor

    Spinorphin is an endogenous factor that exhibits inhibitory effects on enkephalin-degrading enzymes.
  5. AT1 receptor antagonist

    EXP-3174 is a potent and selective noncompetitive AT1 receptor antagonist with IC50 value of 37 nM.
  6. angiotensin II receptor type 1 antagonist

    Azilsartan medoxomil is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension.
  7. non-peptide angiotensin II receptor antagonist

    Fimasartan is a non-peptide angiotensin II receptor antagonist (ARB) used for the treatment of hypertension and heart failure. Through oral administration, fimasartan blocks angiotensin II receptor type 1 (AT1 receptors), reducing pro-hypertensive actions of angiotensin II, such as systemic vasoconstriction and water retention by the kidneys.
  8. Angiotensin II receptor antagonist

    Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.
  9. angiotensin II receptor type 1 antagonist

    Azilsartan medoxomil monopotassium is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension.
  10. angiotensin II and endothelin A receptor antagonist

    Sparsentan (RE-021) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Kis of 0.8 and 9.3 nM, respectively.
  11. angiotensin-(1-7) receptor agonist

    AVE 0991 is a nonpeptide and orally active angiotensin-(1-7) receptor agonist with an IC50 of 21 nM.
  12. Angiotensin-II subtype 2 receptor(AT2 R) agonist

    CGP-42112(CGP-42112A) is a potent Angiotensin-II subtype 2 receptor(AT2 R) agonist.
  13. angiotensin II receptor antagonist

    Losartan D4 Carboxylic Acid is the deuterium labeled Losartan(EXP-3174), which is an angiotensin II receptor antagonist.
  14. angiotensin II type 1 receptor antagonist

    Azilsartan D5 is the deuterium labeled Azilsartan(TAK-536), which is a specific and potent angiotensin II type 1 receptor antagonist.
  15. direct renin inhibitor

    Aliskiren D6 Hydrochloride (CGP 60536 D6 Hydrochloride) is is deuterium labeled Aliskiren, which is a direct renin inhibitor with IC50 of 1.5 nM.

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