Serine/threonine kinase

SRPIN340 is a cell-permeable isonicotinamide that acts as an ATP-competitive SRPK1-selective inhibitor (IC50 = 0.14 and 1.8 μM, respectively, against mSRPK1 and mSRPK2) with much reduced activity against 143 other kinases.

ML-281 is a potent ans selective STK33 inhibitor with IC50 value of 14 nM.

WNK463 is an orally bioavailable pan-WNK-kinase inhibitor.

SGC GAK 1 is a high affinity cyclin G associated kinase (GAK) inhibitor.

ZT-12-037-01 is a potent, selective, ATP-competitive STK19 inhibitor. ZT-12-037-01 effectively blocks oncogenic NRAS-driven melanocyte malignant transformation and melanoma growth in vitro and in vivo.

SPHINX31 is a potent inhibitor of serine/arginine-rich protein kinase 1 (SRPK1; IC50 = 5.9 nM).

STK16-IN-1 is a STK16 kinase inhibitor with an IC50 of 295 nM.