Cytoskeleton

Balamapimod, also known as MKI-822, is a Ras/Raf/MEK inhibitor.

SOS1-IN-1 is a SOS1 inhibitor.

MRTX849 is a potent, orally-available, and mutation-selective covalent inhibitor of KRAS G12C with potential antineoplastic activity.

ARS-1620 is a potent, orally bioavailable covalent inhibitor of KRAS-G12C) and could achieve rapid and sustained in vivo target occupancy to induce tumor regression.

ARS-1630 is a novel inhibitor of mutant K-ras G12C.

BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction with IC50 of 21 nM.

K-Ras-IN-1 is a K-Ras inhibitor, by binding to K-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure.(the detailed information refer to the reference).

RBC10 is an inhibitor of Ral binding to RALBP1 (the effector).