Protein serine/threonine phosphatase

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  1. FK-506 (Tacrolimus)

    Catalog No. A10389
    mTOR inhibitor
    FK-506 is an immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system and so lower the risk of organ rejection. It reduces interleukin-2 (IL-2) production by T-cells. Learn More
  2. Ascomycin

    Catalog No. A12592
    calcineurin inhibitor
    Ascomycin is a potent immunosuppressive agent that could be used as a potential therapeutic agent for autoimmune diseases. Learn More
  3. Calcineurin inhibitory peptide is a selective inhibitor of Ca2+-calmodulin-dependent protein phosphatase (calcineurin) (IC50 ~ 10 uM). Does not inhibit PP1, PP2A or CaM kinase II (IC50 > 100 mM). Learn More
  4. DL-AP3

    Catalog No. A15378
    mGluR1 antagonist
    DL-AP3, a racemic preparation of D-AP3 and L-AP3, is an inhibitor of phosphoserine phosphatase and an antagonist of the metabotropic glutamate receptor (mGluR), blocking phosphoinositide turnover mediated by the mGluR. Learn More
  5. INCA-6

    Catalog No. A15380
    Calcineurin-NFAT inhibitor
    INCA-6 is a potent and selective inhibitor of calcineurin-NFAT (Nuclear Factor of Activated T cells) signaling. Learn More
  6. Ascomycin (FK520)

    Catalog No. A15788
    Calcineurin/PP2B inhibitor
    Ascomycin is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties. It has been researched for the treatment of autoimmune diseases and skin diseases, and to prevent rejection after an organ transplant. Learn More
  7. Cyclosporine

    Catalog No. A15434
    Calcineurin inhibitor
    Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. Learn More

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