TGF-β/Smad

Y-33075 is ROCK (Rho-associated coiled coil-forming protein kinase) inhibitor.

ROCK inhibitor is a highly potent inhibitor of human ROCK-1 and ROCK-2 isoenzymes with IC50 values of 0.6 and 1.1 nM, respectively.

VTX-27 is a selective protein kinase C θ (PKC θ) inhibitor, with Kis of 0.08 nM and 16 nM for PKC θ and PKC δ.

PKC-theta inhibitor is a selective PKC-θinhibitor, with an IC50 of 12 nM.