Membrane Transporters-Ion Channels

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  1. KCa2.1 channels activator

    GW 542573X is an activator of small-conductance Ca2+-activated K+ channels (KCa2).
  2. hERG1 potassium channel activator

    KB130015 is a novel activator of hERG1 potassium channels, blocking native and recombinant hERG1 channels at high voltages, but activating them at low voltages.
  3. TRPA1 activatior/TRPM8 blocker

    Cannabichromene is a major non-psychotropic phytocannabinoid that inhibits endocannabinoid inactivation and activates the transient receptor potential ankyrin-1 (TRPA1). Both endocannabinoids and TRPA1 may modulate gastrointestinal motility.
  4. KV7.2/7.3 activator

    ICA-110381 is a KV7.2/7.3 activator with EC50 of 0.38 uM.
  5. Calcium Channel Activator

    Bay K 8644 is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM.
  6. hERG channel activator

    NS-1643 is a Human ether-a-go-go related gene (hERG) KV11.1 channel activator (EC50 = 10.5 uM).
  7. Oct4 activator

    OAC2 is an Oct4-activating compound which activates expression through the Oct4 gene promoter.
  8. TREK-1 activator

    ML402 is a selective TREK-1 activator.
  9. potassium channel (non-GIRK1/X) activator

    VU0529331 is a modestly selective non-GIRK1-containing G protein-gated, inwardly-rectifying, potassium channel (non-GIRK1/X) activator, with EC50s of 5.1 ?M and 5.2 ?M for GIRK2 and GIRK1/2 in HEK293 cells, respectively, also effective on GIRK4 homomeric channel.
  10. TRPML3 ion channel activator

    SN 2 is a novel and potent activator of TRPML3 ion channel with EC50 of 1.8??0.13 μM.
  11. KATP activator

    Levcromakalim ((-)-Cromakalim) is an ATP-sensitive K+ channel (KATP) activator.

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