Catalog No.

Product Name

Application

Product Information

Product Citation

A11382

Dipraglurant

mGluR5 antagonists

Dipraglurant (ADX 48621) is a mGluR5 antagonists with IC50 of 0.021 μM.

Quick View
A11484

LY341495

mGluR-2 antagonist

LY 341495 has been shown to be a highly potent and selective group II metabotropic glutamate receptor (mGluR-2) antagonist with Ki / IC50 values are 2.3, 1.3, 173, 990, 6800, 8200 and 22000 nM for human mGluR-2, mGluR-3, mGluR-8 , mGluR-7a, mGluR-1a, mGluR-5a and mGluR-4a.

Quick View
A12589

MPEP

mGlu5 receptor antagonist

MPEP is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors.

Quick View
A12705

PHCCC

mGluR antagonist

PHCCC is a group I metabotropic glutamate receptor antagonist (IC50 ~ 3 μM).

Quick View
A13236

MPEP HCl

mGlu5 receptor antagonist

MPEP is a potent, highly selective non-competitive antagonist at the mGlu5a receptor subtype (IC50 = 36 nM) while having no agonist or antagonist activities at the mGlu1b receptor at concentrations up to 30 uM.

Quick View
A13758

SIB 1757

mGluR antagonist

SIB 1757 is a highly selective antagonist for the mGlu5 metabotropic glutamate receptor subtype.

Quick View
A13759

SIB 1893

mGluR antagonist

SIB 1893 is a highly selective non-competitive antagonist for the metabotropic glutamate mGlu5 receptor subtype.

Quick View
A13854

A-841720

mGluR-1 antagonist

A 841720 is a potent, non-competitive mGluR-1 antagonist that displays 34-fold selectivity over mGluR-5 (IC50 values are 10 and 342 nM respectively).

Quick View
A15174

MTEP hydrochloride

mGlu5 antagonist

MTEP hydrochloride is a potent, selective and non-competitive mGlu5 antagonist with IC50 and Ki of 5 nM and 16 nM, respectively.

Quick View
A15378

DL-AP3

mGluR1 antagonist

DL-AP3, a racemic preparation of D-AP3 and L-AP3, is an inhibitor of phosphoserine phosphatase and an antagonist of the metabotropic glutamate receptor (mGluR), blocking phosphoinositide turnover mediated by the mGluR.

Quick View
A19738

AZD 9272

mGluR5 antagonist

AZD 9272 is a brain penetrant mGluR5 antagonist.

Quick View
A20372

Fenobam

mGluR5 antagonist

Fenobam is a selective, orally active, and non-competitive mGluR5 antagonist acting at an allosteric modulatory site (Kd values are 54 and 31 nM for rat and human recombinant mGlu5 receptors, respectively).

Quick View
A20545

JNJ16259685

mGlu1 receptor antagonist

JNJ16259685 is a selective antagonist of mGlu1 receptor, and inhibits the synaptic activation of mGlu1 in a concentration-dependent manner with IC50 of 19 nM.

Quick View
A20549

(S)-MCPG

group I/group II mGluR antagonist

(S)-MCPG is the active isomer of (RS)-MCPG, non-selective group I/group II metabotropic glutamate receptor antagonist.

Quick View
A20567

CFMTI

mGluR 1 allosteric antagonist

CFMTI is a potent and selective metabotropic glutamate receptor (mGluR) 1 allosteric antagonist with IC50 of 2.6 nM.

Quick View
A20804

E4CPG

group I/group II mGluR antagonist

E4CPG is a novel group I/group II metabotropic glutamate receptor antagonist, more potent than (RS)-MCPG .

Quick View
A20818

(RS)-MCPG

group I/group II mGluR antagonist

(RS)-MCPG is a non-selective group I/group II metabotropic glutamate receptor antagonist.

Quick View
A21899

Methoxy-PEPy

mGlu5 receptor antagonist

Methoxy-PEPy is a potent and highly selective mGlu5 receptor antagonist with IC50 of 1 nM.

Quick View
A22629

CPCCOEt

mGluR1b antagonist

CPCCOEt is a low affinity, selective, non-competitive antagonist of the metabotropic glutamate receptor subtype mGluR1b.

Quick View

Metabotropic glutamate receptors (mGluR)