Catalog No.

Product Name

Application

Product Information

Product Citation

A11484

LY341495

mGluR-2 antagonist

LY 341495 has been shown to be a highly potent and selective group II metabotropic glutamate receptor (mGluR-2) antagonist with Ki / IC50 values are 2.3, 1.3, 173, 990, 6800, 8200 and 22000 nM for human mGluR-2, mGluR-3, mGluR-8 , mGluR-7a, mGluR-1a, mGluR-5a and mGluR-4a.

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A12589

MPEP

mGlu5 receptor antagonist

MPEP is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors.

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A13758

SIB 1757

mGluR antagonist

SIB 1757 is a highly selective antagonist for the mGlu5 metabotropic glutamate receptor subtype.

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A13759

SIB 1893

mGluR antagonist

SIB 1893 is a highly selective non-competitive antagonist for the metabotropic glutamate mGlu5 receptor subtype.

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A15174

MTEP hydrochloride

mGlu5 antagonist

MTEP hydrochloride is a potent, selective and non-competitive mGlu5 antagonist with IC50 and Ki of 5 nM and 16 nM, respectively.

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A15378

DL-AP3

mGluR1 antagonist

DL-AP3, a racemic preparation of D-AP3 and L-AP3, is an inhibitor of phosphoserine phosphatase and an antagonist of the metabotropic glutamate receptor (mGluR), blocking phosphoinositide turnover mediated by the mGluR.

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A19738

AZD 9272

mGluR5 antagonist

AZD 9272 is a brain penetrant mGluR5 antagonist.

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A20372

Fenobam

mGluR5 antagonist

Fenobam is a selective, orally active, and non-competitive mGluR5 antagonist acting at an allosteric modulatory site (Kd values are 54 and 31 nM for rat and human recombinant mGlu5 receptors, respectively).

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A20545

JNJ16259685

mGlu1 receptor antagonist

JNJ16259685 is a selective antagonist of mGlu1 receptor, and inhibits the synaptic activation of mGlu1 in a concentration-dependent manner with IC50 of 19 nM.

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A20549

(S)-MCPG

group I/group II mGluR antagonist

(S)-MCPG is the active isomer of (RS)-MCPG, non-selective group I/group II metabotropic glutamate receptor antagonist.

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A20567

CFMTI

mGluR 1 allosteric antagonist

CFMTI is a potent and selective metabotropic glutamate receptor (mGluR) 1 allosteric antagonist with IC50 of 2.6 nM.

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A20804

E4CPG

group I/group II mGluR antagonist

E4CPG is a novel group I/group II metabotropic glutamate receptor antagonist, more potent than (RS)-MCPG .

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A20818

(RS)-MCPG

group I/group II mGluR antagonist

(RS)-MCPG is a non-selective group I/group II metabotropic glutamate receptor antagonist.

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A21899

Methoxy-PEPy

mGlu5 receptor antagonist

Methoxy-PEPy is a potent and highly selective mGlu5 receptor antagonist with IC50 of 1 nM.

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A22629

CPCCOEt

mGluR1b antagonist

CPCCOEt is a low affinity, selective, non-competitive antagonist of the metabotropic glutamate receptor subtype mGluR1b.

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Metabotropic glutamate receptors (mGluR)