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$0.00 ADAMs
The ADAMs (a disintegrin and metalloproteases) family of transmembrane proteins belongs to the zinc protease superfamily. Members of the family have a modular design, characterized by the presence of metalloprotease and integrin receptor-binding activities, and a cytoplasmic domain that in many family members specifies binding sites for various signal transducing proteins. The ADAMs family has been implicated in the control of membrane fusion, cytokine and growth factor shedding, and cell migration, as well as processes such as muscle development, fertilization, and cell fate determination.
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TAPI-1
Catalog No. A14070 TACE/MMP inhibitorTAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors. Learn More -
TAPI-0
Catalog No. A13724 TACE/MMP inhibitorTAPI-0 is an inhibitor of TACE (IC50 = 50-100 nM) as well as other matrix and membrane metalloproteases Learn More -
TAPI-2
Catalog No. A14009 TACE/MMP inhibitorTAPI-2 is an inhibitor of TACE, ADAMs, ACE secretase, and other MMPs (metalloproteinases). TAPI-2 blocks release of DCC7, APP, TNFα, L-selectin, NOTCH, TGFα, IL-6R9, erbB2/HER2, and ACE. This inhibitor has been used in tissue culture. Learn More -
GI 254023X
Catalog No. A15322 ADAM10 metalloprotease inhibitorGI 254023X is a selective ADAM10 metalloprotease inhibitor; displays over 100-fold higher potency at ADAM10 compared to ADAM17. Learn More -
TMI-1
Catalog No. A17212 TACE/MMP inhibitorTMI-1 is a novel orally active dual inhibitor of ADAM17 (TACE) and MMP. Learn More
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