Kinesin

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  1. KSP Inhibitor

    SB 743921, a second generation KSP inhibitor, is a highly potent and active therapeutic in preclinical models of cancer.
  2. CENP-E inhibitor

    GSK-923295, is a small-molecule inhibitor of the mitotic kinesin centromere-associated protein E, (CENP-E).
  3. Microtubule Associated inhibitor

    CW069 is an allosteric, and selective inhibitor of microtubule motor protein HSET with IC50 of 75 uM, significant selectivity over KSP.
  4. Eg5 mitotic motor protein inhibitor

    ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor.
  5. Mps1 inhibitor

    MPI-0479605 is an ATP competitive and selective inhibitor of mitotic kinase Mps1
  6. Kinesin Eg5 inhibitor

    Dimethylenastron is an inhibitor of mitotic motor kinesin Eg5 with IC50 value of 200 nM.
  7. Kinesin inhibitor

    EMD534085 is a kinesin inhibitor currently in clinical development.
  8. MPS1 checkpoint inhibitor

    BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint with an IC50 of 2 nM.
  9. HSET/KIFC1 inhibitor

    AZ82 is a selective kinesin-like protein KIFC1 (HSET/KIFC1) inhibitor, with a Ki of 43 nM and an IC50 of 300 nM for KIFC1.
  10. kinesin Eg5 inhibitor

    Litronesib (Racemate) is the racemate of litronesib. Litronesib is a selective, allosteric inhibitor of kinesin Eg5.
  11. MPS1 inhibitor

    NMS-P715 is a selective, ATP-competitive inhibitor of MPS1, with an IC50 of 182 nM.
  12. mitosis-specific kinesin Eg5 inhibitor

    Litronesib is a selective mitosis-specific kinesin Eg5 inhibitor, with antitumor activity.

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