DNA alkylator

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  1. Bendamustine HCl (SDX-105)

    Catalog No. A10124
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    Bendamustine Hydrochloride is a small molecule bifunctional DNA alkylating agent, combining a nitrogen mustard functionality with a purine-analog structure. The dense DNA-damaging functionality of Bendamustine differentiates it from other compounds used as antiproliferative agents, and these functionalities are thought to promote cell death through a variety of different pathways including apoptosis and mitotic catastrophe.

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  2. Altretamine

    Catalog No. A10059
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    Altretamine is classified as an alkylating antineoplastic agent.This unique structure is believed to damage tumor cells through the production of the weakly alkylating species formaldehyde, a product of CYP450-mediated N-demethylation. Learn More
  3. Cyclophosphamide monohydrate

    Catalog No. A11635
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    Cyclophosphamide monohydrate is an alkylating, cytotoxic agent experimentally shown to crosslink DNA, causing strand breakage and inducing mutations. Learn More
  4. Uramustine

    Catalog No. A13473
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    Uramustine is a chemotherapy drug which belongs to the class of alkylating agents. Learn More
  5. Miriplatin hydrate

    Catalog No. A15162
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    Miriplatin hydrate is a lipophilic platinum complex containing myristates as leaving groups, and can be easily suspended in ethyl esters of iodized fatty acids obtained from poppy seed oil. Learn More
  6. VAL-083

    Catalog No. A15269
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    bi-functional alkylating agent
    VAL-083 is a bi-functional alkylating agent; inhibit U251 and SF188 cell growth in monolayer better than TMZ and caused apoptosis. Learn More
  7. Melphalan

    Catalog No. A15344
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    DNA alkylating agent
    Melphalan is a cytotoxic drug used to treat multiple myeloma. Phenylamine derivative of mechorethamine. Learn More
  8. Thiotepa

    Catalog No. A10930
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    Thiotepa is a polyfunctional, organophosphorus alkylating agent and a stable derivative of N,N',N''-triethylenephosphoramide (TEPA), with antineoplastic activity. Learn More

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