Sirtuins

EX 527 is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with IC50 of 38 nM in a cell-free assay.

Sirtinol is a cell-permeable, specific inhibitor of sirtuin NAD-dependant histone deacetylases. It is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM in cell-free assays, respectively.

Salermide is an inhibitor of Sirt1 and Sirt2; can cause strong cancer-specific apoptotic cell death.

Cambinol is a SIRT1 and SIRT2 inhibitor with IC50 values of 56 and 59 μM, respectively.

Inauhzin is a potent SIRT inhibitor, which effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress.

AK-1 inhibits SIRT2 selectively over SIRT1 and SIRT3.

SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.

OSS-128167, also known as SIRT6-IN-1, is a potent and selective SIRT 6 inhibitor with IC50 value of 89 μM.

3-TYP is a SIRT3 inhibitor.

Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM.

JFD00244 is a sirtuin 2 (SIRT2) inhibitor. Anti-tumor effect.