GPR

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  1. OC 000459

    Catalog No. A11946
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    CRTH2 antagonist
    OC 000459 is a potent, oral and selective CRTH2 (also known as DP2) antagonist. Learn More
  2. NCRW0005-F05

    Catalog No. A16184
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    GPR139 antagonist
    NCRW0005-F05, first antagonist selective for GPR139 (IC50 value 0.21 uM); a useful tool to study GPR139 pharmacology, especially in combination with the GPR139 agonist JNJ 63533054. Learn More
  3. TUG-770

    Catalog No. A12994
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    FFA1/GPR40 Agonist
    TUG-770 is a Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes. Learn More
  4. Versipelostatin

    Catalog No. A16069
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    Versipelostatin is a novel GRP78/Bip molecular chaperone down-regulator of microbial origin that was isolated from the metabolite of Streptomyces versipellis strain 4083-SVS6. Learn More
  5. GSK137647A

    Catalog No. A14542
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    FFA4/GPR120 agonist
    GSK137647A is a selective FFA4 agonist, with pEC50 of 6.3, 6.2, and 6.1 for human, Mouse and Rat FFA4, respectively. Learn More
  6. APD597 (JNJ-38431055)

    Catalog No. A15452
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    GPR119 agonist
    APD597 is a GPR119 agonist intended for the treatment of type 2 diabetes, with EC50 of 46 nM for hGPR119. Learn More
  7. NIBR189

    Catalog No. A15775
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    EBI2 (GPR183) receptor antagonist
    NIBR189 is a small molecule antagonist of the Epstein-Barr virus-induced gene 2 (EBI2; GPR183) receptor with IC50 of 16 nM(Binding) and 11 nM (Functional). Learn More
  8. 6-OAU

    Catalog No. A15507
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    GPR84 agonist
    6-OAU is a surrogate agonist of GPR84; activates human GPR84 in the presence of Gqi5 chimera in HEK293 cells with an EC50 of 105 nM in the PI assay. Learn More
  9. GPR120 modulator 2

    Catalog No. A15095
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    GPR120 modulator 2 is useful for modulating G protein-coupled receptor 120 (GPR120). Learn More
  10. GPR120 modulator 1

    Catalog No. A15094
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    GPR120 modulator 1 is useful for modulating G protein-coupled receptor 120 (GPR120). Learn More
  11. Deoxycholic acid

    Catalog No. A14952
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    Deoxycholic acid, extracted from Pig bile, Suitability:Ethanol,ether,three oxygen methane,acetone,acetic acid,alkali hydroxide and alkali carbonate solution. Learn More
  12. AMG 837

    Catalog No. A13468
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    GPR40/FFA1 agonist
    AMG-837 is a potent, orally bioavailable GPR40 agonist. Learn More
  13. APD668

    Catalog No. A14342
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    GPR119 agonist
    APD668 is a potent GPR119 agonist with EC50 of 2.7 nM and 33 nM for hGPR119 and ratGPR119 respectively. Learn More
  14. AZD1981

    Catalog No. A13186
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    CRTH2 receptor antagonist
    AZD1981, as a potent antagonist in a disease relevant cell system, inhibits DK-PGD2-induced CD11b expression in human eosinophils with IC50 of 10 nM. Learn More
  15. AR-231453

    Catalog No. A13716
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    GPR119 agonist
    AR-231453 is a potent and selective small molecule agonis of GPR119 that enhances glucose dependent insulin secretion and glucagon like peptide-1 (GLP-1) release. Learn More
  16. MBX-2982

    Catalog No. A12634
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    GPR119 agonist
    MBX-2982 is a potential first-in-class treatment for type 2 diabetes that targets G protein-coupled receptor 119 (GPR119), a receptor that interacts with bioactive lipids known to stimulate glucose-dependent insulin secretion. Learn More
  17. Diphenyleneiodonium chloride

    Catalog No. A13359
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    GPR3 agonist/NOS/ NADPH oxidases inhibitor
    Diphenyleneiodonium chloride has been shown to be a potent irreversible inhibitor of NOS2 (iNOS) from macrophages and NOS3 (eNOS) from endothelial cells. Learn More
  18. TC-G-1008

    Catalog No. A16364
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    GPR39 agonist
    TC-G-1008 is a GPR39 (zinc receptor) agonist (EC50 values are 0.4 and 0.8 nM for rat and human receptors respectively). Learn More

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