Catalog No.

Product Name

Application

Product Information

Product Citation

A12575

APG-115

MDM2 inhibitor

APG-115 (AA-115) is an orally active MDM2 protein inhibitor binding to MDM2 protein with IC50 and Ki values of 3.8 nM and 1 nM, respectively.

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A13480

MA242

dual MDM2/NFAT1 inhibitor

MA242 is a dual inhibitor of murine double minute 2 (MDM2) and nuclear factor of activated T cells 1 (NFAT1) for Pancreatic Cancer Therapy.

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A14051

WK23

MDM2/MDMX inhibitor

WK23 is an inhibitor based on four aromatic groups and able to efficiently fill the binding pockets of MDM2/MDMX, its median inhibitory concentration (IC50) values to MDM2/MDMX are 1.17 and 36 uM, respectively

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A18450

MI-1061

MDM2 inhibitor

MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). MI-1061 potently activates p53, induces apoptosis, and has anti-tumor activity.

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A18813

RO-5963

MDM2/MDMX inhibitor

RO-5963 is an inhibitor of the interaction of both MDM2 and MDMX with p53 with IC50s of ~17 nM and ~24 nM, respectively.

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A18877

PROTAC MDM2 Degrader-4

MDM2 inhibitor

PROTAC MDM2 Degrader-4 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-4 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase.

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A18883

PROTAC MDM2 Degrader-3

MDM2 degrader

PROTAC MDM2 Degrader-3 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-3 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase.

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A18890

PROTAC MDM2 Degrader-2

MDM2 inhibitor

PROTAC MDM2 Degrader-2 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-2 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase.

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A18897

PROTAC MDM2 Degrader-1

MDM2 degrader

PROTAC MDM2 Degrader-1 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-1 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase.

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A18917

Nutlin carboxylic acid

Nutlin 3-based MDM2 ligand

Nutlin carboxylic acid (MDM2 ligand 1) is the Nutlin 3-based MDM2 ligand. Nutlin carboxylic acid (MDM2 ligand 1) can be connected to the ligand for protein by a linker to form PROTACs.

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A18924

(4R,5S)-nutlin carboxylic acid

Nutlin 3-based MDM2 ligand

(4R,5S)-nutlin carboxylic acid (MDM2 ligand 2) is the Nutlin 3-based MDM2 ligand. (4R,5S)-nutlin carboxylic acid can be connected to the ligand for protein by a linker to form PROTACs.

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A20824

BI-0252

MDM2-p53 inhibitor

BI-0252 is an orally active, selective MDM2-p53 inhibitor with an IC50 of 4 nM.

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Natural Products