Beta-secretase (BACE)

LY2886721 is a novel potent agent that is used to treat Alzheimer's Disease in preclinical experiments.

LY2811376 is the first orally available non-peptidic BACE1 inhibitor that produces profound Aβ-lowering effects in animals.

Verubecesta is a potent and selective beta-secretase inhibitor, and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor.

Eslicarbazepine is an oral anticonvulsant indicated for the adjunctive treatment of partial seizures.

LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM.