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Application
Product Information
Product Citation
- Collagen proline hydroxylase inhibitor-1 is an antifibroproliferative agents.
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Glyoxalase I inhibitor
Glyoxalase I inhibitor is a potent Glyoxalase I inhibitor, candidate for anticancer agents. -
neuromuscular blocker
Rocuronium (Org-9426) is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia. - Benperidol has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders, among others.
- Ombrabulin is a synthetic water-soluble analogue of combretastatin A4, derived from the South African willow bush (Combretum caffrum), with potential vascular-disrupting and antineoplastic activities.
- Teglarinad chloride, also known as GMX1777, is a water-soluble prodrug of a cyanoguanidine compound with potential antineoplastic activity. In vivo, teglarinad chloride is rapidly converted into active drug through hydrolytic cleavage of a carbonate ester bond.
- RC-3095 is a bombesin/gastrin-releasing peptide (BN/GRP) antagonist with potential anticancer activity.
- Paula J.S. Pereira, .et al. , J Neurosci, 2015, Dec 9; 35(49): 16272-16281 PMID: 26658875
- Cardiolipin is an important component of the inner mitochondrial membrane, where it constitutes about 20% of the total lipid composition.
- Ceftobiprole medocaril is a fifth-generation[2] cephalosporin antibiotic with activity against methicillin-resistant Staphylococcus aureus, penicillin-resistant Streptococcus pneumoniae, Pseudomonas aeruginosa, and enterococci.
- Cangrelor is a potent intravenous adenosine diphosphate-receptor antagonist
- Satoru Koyanagi, .et al. , Nat Commun, 2016, 7: 13102 PMID: 27739425
- Lomifylline is a methylxanthine analogue which induces Ca2+-release from intracellular stores via the ryanodine receptor.
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MC4 antagonist
SNT207858 is a 22 nM MC4 antagonist with a 170-fold selectivity vs. MC3 and a 40-fold selectivity versus MC5. - 4-Epi Minocycline is an impurity of Minocyclin, a second generation tetracycline antibiotic.
- GATA4-NKX2-5-IN-1 (Compound 3) dose-dependently inhibits the GATA4?CNKX2-5 transcriptional synergy with an IC50 of 3 μM.
- Deferitrin (GT-56-252) is the first drug in a class of desferrithiocin-derived hexadentate iron chelators.
- BMS-747158-02 is a fluorine 18?Clabeled pyridaben derivative designed as a new myocardial perfusion imaging agent for use with positron emission tomography (PET).
- Metazathioprine is a methylated derivative of azathioprine (AZA). It demonstrated the greatest values of apparent and specific partition coefficients in n-octanol/phosphate buffer at pH 5.7 and pH 7.4 among purine derivatives such as 6-mercaptopurine (6-MP), 6-thioguanine (6-TG) and AZA.
- EC-17 is a conjugate consisting of fluorescein isothiocyanate (FITC) conjugated with folate with potential antineoplastic activity.
- Chu W, .et al. , Biosci Trends, 2018, Jul 17;12(3):298-308 PMID: 29899195
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morpholino antisense oligomer
Eteplirsen is an experimental drug, currently in clinical trials. - sodium 4-pentynoate is a alkynylacetate analogue; can be metabolically incorporated onto cellular proteins through biosynthetic mechanisms for profiling of acetylated proteins in diverse cell types.
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MyD88 dimerization Inhibitor
ST 2825 is a MyD88 pharmacologic inhibitor.- Bernard Kan, .et al. , Nat Commun, 2018, 9: 4822 PMID: 30446641
- Shira Dishon, .et al. , Sci Rep, 2018, 8: 9476 PMID: 29930295
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NRP1 antagonist
EG01377 TFA salt is a selective neuropilin-1 (NRP1) antagonist. CAS: 2227996-00-9 (Free base) -
sedative and anxiolytic
Lofendazam is a benzodiazepine derivative that has sedative and anxiolytic effects. - Thiamine diphosphate analog 1 is an analog of Thiamine diphosphate. Thiamine diphosphate is the active form of vitamin B1. Thiamine diphosphate a universal cofactor involved in pivotal cellular pathways.
- ITIC, non-fullerene acceptor, is an indacenodithienothiophene-based postfullerene electron acceptor, crystallizes in a profoundly different way as compared to fullerenes. ITIC has a superior thermal stability and undergoes a glass-crystal transition considerably below its high Tg of 180 ??C.
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FER tyrosine kinase inhibitor
DS21360717 is a potent and orally active FER tyrosine kinase inhibitor, with an IC50 of 0.49 nM. Anti-cancer activity. -
ATAD5 inhibitor
ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization, acts as a probe molecule that has low micromolar inhibitory activity. ML367 blocks DNA repair pathways, suppresses general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation.
