Sigma receptor

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  1. Ditolylguanidine

    Catalog No. A21268
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    Sigma receptor agonist
    Ditolylguanidine (1,3-Di-o-tolylguanidine) is an agonist of sigma receptor (??1/??2 receptor). Learn More
  2. Cutamesine

    Catalog No. A21152
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    sigma 1 receptor agonist
    Cutamesine (SA4503; AGY-94806) is a selective sigma 1 receptor(??1R) agonist; high affinity for the sigma 1 receptor subtype labeled by (+)-[3H]pentazocine (IC50= 17.4??1.9 nM); 100-fold less affinity for the sigma 2 receptor. Learn More
  3. Sigma-1 receptor antagonist 3

    Catalog No. A18501
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    Sigma-1 receptor antagonist
    Sigma-1 receptor antagonist 3 (compound135) is a potent and selective Sigma-1 (??1) receptor antagonist with a Ki of 1.14 nM. Learn More
  4. Sigma-1 receptor antagonist 2

    Catalog No. A18504
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    sigma 1 receptor antagonist
    Sigma-1 receptor antagonist 2 is a potent and selective sigma 1 receptor (??1 R) antagonist with Kis of 3.88 and 1288 nM for ??1 and ??2 receptor, respectively. Learn More
  5. E1R

    Catalog No. A18825
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    sigma-1 receptors modulator
    E1R is a novel positive allosteric modulator of sigma-1 receptors. Learn More
  6. 4-IBP

    Catalog No. A12314
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    σ1 agonist
    4-IBP is a selective σ1 agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM) . Learn More
  7. Glycerol phenylbutyrate

    Catalog No. A18201
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    sigma-2 (σ2) receptor ligand
    Glycerol phenylbutyrate is a sigma-2 (σ2) receptor ligand, with a pKi of 8.02. Learn More
  8. SA-4503

    Catalog No. A12984
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    sigma 1 receptor(σ1R) agonist
    SA4503 is a selective sigma 1 receptor(σ1R) agonist; high affinity for the sigma 1 receptor subtype labeled by (+)-[3H]pentazocine (IC50 = 17.4 +/- 1.9 nM); 100-fold less affinity for the sigma 2 receptor. Learn More
  9. BD-1047 2HBr

    Catalog No. A13196
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    Sigma-1 antagonist
    BD-1047 2HBr is a selective functional antagonist of sigma receptors, shows antipsychotic activity in animal models predictive of efficacy in schizophrenia. Learn More
  10. UMB24

    Catalog No. A13513
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    Sigma2 antagonist
    UMB24 is a putative sigma2-preferring antagonist. Learn More
  11. Siramesine

    Catalog No. A13036
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    Sigma-2 receptor agonist
    Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation. Learn More
  12. S1RA

    Catalog No. A12504
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    sigma-1 receptor antagonist
    S1RA is a selective sigma-1 receptor antagonist, with a reported binding affinity of Ki = 17.0 ± 7.0 nM, selective over the sigma-2 receptor and against a panel of other 170 receptors, enzymes, transporters and ion channels. Learn More
  13. Siramesine Hydrochloride

    Catalog No. A12479
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    Sigma-2 receptor agonist
    Siramesine Hydrochloride is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer activity in vivo. Learn More

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