Sigma receptor

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  1. Siramesine Hydrochloride

    Catalog No. A12479
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    Sigma-2 receptor agonist
    Siramesine Hydrochloride is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer activity in vivo. Learn More
  2. S1RA

    Catalog No. A12504
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    sigma-1 receptor antagonist
    S1RA is a selective sigma-1 receptor antagonist, with a reported binding affinity of Ki = 17.0 ± 7.0 nM, selective over the sigma-2 receptor and against a panel of other 170 receptors, enzymes, transporters and ion channels. Learn More
  3. Siramesine

    Catalog No. A13036
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    Sigma-2 receptor agonist
    Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation. Learn More
  4. UMB24

    Catalog No. A13513
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    Sigma2 antagonist
    UMB24 is a putative sigma2-preferring antagonist. Learn More
  5. BD-1047 2HBr

    Catalog No. A13196
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    Sigma-1 antagonist
    BD-1047 2HBr is a selective functional antagonist of sigma receptors, shows antipsychotic activity in animal models predictive of efficacy in schizophrenia. Learn More
  6. SA-4503

    Catalog No. A12984
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    sigma 1 receptor(σ1R) agonist
    SA4503 is a selective sigma 1 receptor(σ1R) agonist; high affinity for the sigma 1 receptor subtype labeled by (+)-[3H]pentazocine (IC50 = 17.4 +/- 1.9 nM); 100-fold less affinity for the sigma 2 receptor. Learn More

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