Sirtuins

Catalog No.Inhibitor Name SIRT1SIRT2SIRT3SirtuinOther
A10377Selisistat (EX 527)
****
A12226Sirtinol
*
**
A15902SirReal2
****
A14221Splitomicin
**
A14225AGK2
***
A12305Tenovin-6
***
*
p53

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

10 Item(s)

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  1. SRT 1720

    Catalog No. A15247
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  2. SRT1720 HCl

    Catalog No. A10862
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    SIRT1 Activator
    SRT1720 is an inhibitor developed intended as a small-molecule activator of the sirtuin subtype SIRT1. Learn More
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    MDL-800

    Catalog No. A17228
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    SIRT6 allosteric activator
    MDL-800 is a first-in-class cellularly active SIRT6 allosteric activator. Learn More
  3. CAY10602

    Catalog No. A19395
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    SIRT1 activator
    CAY10602 is a SIRT1 activator. Learn More
  4. SRT 1460

    Catalog No. A19026
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    SIRT1 activator
    SRT 1460, a potent Sirtuin-1 (SIRT1) activator with an EC1.5 value of 2.9 μM, shows good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 μM), and is more potent than Resveratrol and the closest sirtuin homologues. Learn More
  5. UBCS039

    Catalog No. A18961
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    SIRT6 activator
    UBCS039 is the first synthetic, specific Sirtuin 6 (SIRT6) activator, inducing autophagy in human tumor cells, with an EC50 of 38 μM. Learn More
  6. SRT 2183

    Catalog No. A12150
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    Sirtuin-1 (SIRT1) activator
    SRT 2183 is a selective Sirtuin-1 (SIRT1) activator with an EC1.5 value of 0.36 μM. SRT 2183 induces growth arrest and apoptosis, concomitant with deacetylation of STAT3 and NF-κB, and reduction of c-Myc protein levels. Learn More
  7. SRT 1720 Hydrochloride

    Catalog No. A21143
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    SIRT1 activator
    SRT 1720 Hydrochloride is a selective activator of SIRT1 with an EC50 of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3. Learn More
  8. Tenovin-6

    Catalog No. A12305
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    p53 activator
    Tenovin-6 is a analog of tenovin-1. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 values of 21, 10, and 67 uM, respectively. Learn More
  9. SRT2104 (GSK2245840)

    Catalog No. A14188
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    SIRT1 activator
    SRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis. Phase 2. Learn More

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