Sirtuins

Catalog No.Inhibitor Name SIRT1SIRT2SIRT3SirtuinOther
A10377Selisistat (EX 527)
****
A12226Sirtinol
*
**
A15902SirReal2
****
A14221Splitomicin
**
A14225AGK2
***
A12305Tenovin-6
***
*
p53

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. SRT 1720

    Catalog No. A15247
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  2. SRT1720 HCl

    Catalog No. A10862
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    SIRT1 Activator
    SRT1720 is an inhibitor developed intended as a small-molecule activator of the sirtuin subtype SIRT1. Learn More
  3. SRT2104 (GSK2245840)

    Catalog No. A14188
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    SIRT1 activator
    SRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis. Phase 2. Learn More
  4. Tenovin-6

    Catalog No. A12305
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    p53 activator
    Tenovin-6 is a analog of tenovin-1. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 values of 21, 10, and 67 uM, respectively. Learn More
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    MDL-800

    Catalog No. A17228
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    SIRT6 allosteric activator
    MDL-800 is a first-in-class cellularly active SIRT6 allosteric activator. Learn More

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