β-Amyloid

Inhibitory Selectivity
Catalog No.Inhibitor Name Beta AmyloidOther
A10288DAPT (GSI-IX)
**
A10802RO4929097
***
γ secretase,γ secretase(ICN)
A11194MK-0752
***
A10157Avagacestat
****
A11776LY2811376
*
BACE1

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A10802 SALE

RO4929097

Gamma-secretase inhibitor
RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM.
A10157

BMS-708163

Gamma-secretase inhibitor
BMS-708163 is an oral gamma secretase inhibitor designed for selective inhibition of amyloid beta synthesis.
A11194 SALE

MK-0752

Gamma-secretase inhibitor
MK-0752 inhibits the Notch signaling pathway, which may result in induction of growth arrest and apoptosis in tumor cells in which the Notch signaling pathway is overactivated.
A10312 SALE

Dimebon 2HCl

Neuroprotectant
Dimebon dihydrochloride is a non-selective antihistamine that displays cognitive enhancing abilities.
A11776 SALE

LY2811376

BACE1 inhibitor
LY2811376 is the first orally available non-peptidic BACE1 inhibitor that produces profound Aβ-lowering effects in animals.
A12647

Ro 90-7501

amyloid β42 inhibitor
Ro 90-7501 is an inhibitor of amyloid β42 (Aβ42) fibril assembly; reduces Aβ42-induced toxicity (EC50 = 2 μM).
A15424

Amyloid b-Protein (1-15)

-
Beta-amyloid protein (A beta), a 39-43 amino acid peptide composed of a portion of the transmembrane domain and the extracellular domain of the amyloid precursor protein (APP), is also the principal component of amyloid.
A15423

beta-Amyloid (1-11)

-
Beta-amyloid (1-11) (Abeta) is a peptide with the sequence H-{Asp}{Ala}{Glu}{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}-OH,which is processed from the Amyloid precursor protein.
A15421

Amyloid b-Peptide (1-43) (human)

-
Amyloid b-Peptide (1-43) (human), amyloid β peptide fragment. Highly toxic, showing higher neurotoxicity compared to Aβ40 and Aβ42.
A15420

Amyloid b-peptide (1-42) (rat)

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Amyloid b-peptide (1-42) (rat)
A15419

Amyloid b-peptide (1-40) (rat)

-
Amyloid b-peptide (1-40) (rat)
A15418

Amyloid b-Peptide (1-40) (human)

-
Amyloid b-Peptide (1-40) (human) is a peptide processed from the amyloid precursor protein (APP).
A15416 SALE

Amyloid b-peptide (25-35) (human)

-
Amyloid b-peptide (25-35) (human), fragment of human amyloid beta-peptide, functionally required for the neurotrophic and neurotoxic effects associated with Alzheimer's disease.
A15417

Amyloid b-Peptide (12-28) (human)

-
Amyloid b-Peptide (12-28) (human), amyloid b-peptide fragment; minimum section required to bind to brain proteins.
A15415

Amyloid b-Peptide (10-20) (human)

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Amyloid b-Peptide (10-20) (human), soluble amyloid b-peptide fragment that is a substrate for gelatinase A/type IV collagenase/MMP-2 and APP secretase; cleaved between Lys16 and Leu17.
A15414

Amyloid b-peptide (42-1) (human)

-
Amyloid b-peptide (42-1) (human), inactive control for Amyloid b (1-42) peptide.
A14075

Amyloid b-Peptide (1-42) (human)

-
Amyloid beta (A?? or Abeta) is a peptide of 36?C43 amino acids that is processed from the Amyloid precursor protein.
A13094

alpha-Amyloid Precursor Protein Modulator

-

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