GPCR/G Protein

AMG-073 HCl (Cinacalcet HCl) represents a new class of compounds for the treatment of hyperparathyroidism known as calcimimetics, which reduce parathyroid hormone (PTH) synthesis and secretion by increasing the sensitivity of the parathyroid calcium-sensing receptor (CaR) to extracellular calcium.

AMG-073 (Cinacalcet) represents a new class of compounds for the treatment of hyperparathyroidism.

YC-1 is a direct activator of soluble Guanylyl Cyclase (sGC), independent of Nitric Oxide.

Mirabegron is a potent bladder relaxant and reagent for diabetes remedy.

Saikosaponin B2 is a saponin activator.

BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator.

C-DIM12 is a novel synthetic activator of Nurr1. C-DIM12 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro.

20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo) that activates the hedgehog (Hh) signaling pathway with an EC50 of 3 μM in a gene transcription reporter assay using NIH3T3 cells.

Guanosine 5'-triphosphate trisodium salt (5'-GTP trisodium salt) is an activator of signal transduction of G proteins.