Antimetabolite

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  1. Flupirtine maleate

    Catalog No. A10251
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    NMDA antagonist
    Non-opioid analgesic with muscle relaxant properties. Learn More
  2. Decitabine

    Catalog No. A10292
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    DNA Methyltransferase Inhibitors
    Decitabine is a hypomethylating agent.It hypomethylates DNA by inhibiting DNA methyltransferase. Learn More
  3. Daphnetin

    Catalog No. A10286
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    EGFR, PKA,PKC inhibitor
    Daphnetin is a coumarin analog that acts as an inhibitor of several protein kinases. It inhibits EGFR kinase (IC50 = 7.67 µM), PKA (IC50 = 9.33 µM), and PKC (IC50 = 25 µM), in vitro. The inhibition of EGFR kinase by daphnetin was competitive to ATP and non-competitive to the peptide substrate. Also acts as a potent antioxidant and anti-malarial agent. Learn More
  4. Capecitabine (Xeloda)

    Catalog No. A10177
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    Capecitabine is a prodrug, that is enzymatically converted to 5-fluorouracil in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. The activation of capecitabine follows a pathway with three enzymatic steps and two intermediary metabolites, 5'-deoxy-5-fluorocytidine (5'-DFCR) and 5'-deoxy-5-fluorouridine (5'-DFUR), to form 5-fluorouracil.

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  5. Cladribine

    Catalog No. A10223
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    Cladribine is a synthetic anti-cancer agent that mimics the nucleoside adenosine and thus inhibits the enzyme adenosine deaminase, which interferes with the cell's ability to process DNA. Learn More
  6. Fludarabine Phosphate (Fludara)

    Catalog No. A10395
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    Fludarabine or fludarabine phosphate (Fludara) is a chemotherapy drug used in the treatment of hematological malignancies (cancers of blood cells such as leukemias and lymphomas) .Fludarabine inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase. It is active against both dividing and resting cells. Learn More
  7. Fludarabine (Fludara)

    Catalog No. A10396
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    STAT inhibitor
    Fludarabine or fludarabine phosphate (Fludara) is a chemotherapy drug used in the treatment of hematological malignancies (cancers of blood cells such as leukemias and lymphomas) .Fludarabine inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase. It is active against both dividing and resting cells. Learn More
  8. Carmofur

    Catalog No. A10183
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    Carmofur is a pyrimidine analogue used as an antineoplastic agent. It is a derivative of fluorouracil. Learn More
  9. Lometrexol disodium

    Catalog No. A15980
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    Lometrexol is a folate analog antimetabolite with antineoplastic activity. Learn More
  10. LY2334737

    Catalog No. A15981
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    broad spectrum antimetabolite
    LY2334737 is an orally available valproic acid ester of gemcitabine, a broad-spectrum antimetabolite with antineoplastic activity. Learn More

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