AhR

ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR), binding directly to AHR, with a Ki of 3 nM. ITE also has immunosuppressive activity.

GNF351 is a full aryl hydrocarbon receptor (AHR) antagonist.

StemRegenin 1 (SR1) is a cell-permeable purine derivative that acts as an antagonist of aryl hydrocarbon receptor and promotes the self-renewal of hematopoietic stem cells (HSCs).

CH-223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor.

L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist.

PDM2 is a selective, high-affinity aryl hydrocarbon receptor (AhR) antagonist with an Ki of 1.2±0.4 nM.

CAY 10465 is a selective and high-affinity AhR agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM).

AHR antagonist 1 is an aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2017202816A1, example 23, has an IC50 of 39.9 nM in human cell line.

1,4-Chrysenequinone, a polycyclic aromatic quinone, acts as an activator of aryl hydrocarbon receptor (AhR).

FICZ is a potent aryl hydrocarbon receptor (AhR) agonist with a Kd of 70 pM.

SGA360 is a selective modulator of aryl hydrocarbon (Ah) receptor that exhibits anti-inflammatory properties.

NSC-703786 (5F-203) is a cytotoxic molecule that forms DNA adducts leading to cell death. NSC-703786 induces aryl hydrocarbon receptor signaling, and elevates expression of CYP1A1. Treatment of cells with NSC-703786 also leads to elevation of reactive oxygen species and activation of p38, JNK and ERK.