E3 ligase

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  1. TAME

    Catalog No. A10884
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    APC/C inhibitor
    TAME is a small molecule anaphase-promoting complex/cyclosome (APC) inhibitor with an IC50 of 12 μM. Learn More
  2. SMER-3

    Catalog No. A13253
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    Ubiquitin E3 Ligase Inhibitor
    SMER3 is a selective inhibitor of a yeast SCF family E3 ubiquitin ligase (SCFMet30) in vitro and in vivo. Induces the expression of MET genes; blocks cell proliferation. Learn More
  3. HLI-98C

    Catalog No. A13654
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    Hdm2 ubiquitin ligase Inhibitor
    HLI-98C, an analog, indeed inhibited Mdm2 E3 ligase activity. Learn More
  4. HLI 373

    Catalog No. A15347
    HDM2 inhibitor
    HLI 373 is an inhibitor of Hdm2 ubiquitin ligase (E3) which blocks Hdm2-mediated ubiquitylation, proteasomal degradation of p53 and activates p53-dependent transcription. Learn More
  5. PRT 4165

    Catalog No. A15453
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    Bmi1/Ring1A inhibitor
    PRT 4165 is an inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1). It prevents Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2alpha. Learn More
  6. Thalidomide

    Catalog No. A10924
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    E3 ubiquitin ligase inhibitor
    Thalidomide can directly inhibit angiogenesis induced by bFGF or VEGF in vivo. Learn More
  7. Avadomide (CC-122)

    Catalog No. A16854
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    E3 Ligase inhibitor
    Avadomide(CC-122), a new chemical entity termed pleiotropic pathway modifier, is a novel agent for Diffuse large B-cell lymphoma(DLBCL) with antitumor and immunomodulatory activity. Its molecular target is the protein cereblon (CRBN), a substrate receptor of the cullin ring E3 ubiquitin ligase complex CRL4CRBN. Learn More

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