DNA Methyltransferases

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  1. DNMT inhibitor

    Azacitidine is a chemical analogue of the cytosine nucleoside used in DNA and RNA that is mainly used in the treatment of myelodysplastic syndrome (MDS).
  2. DNA Methyltransferase Inhibitors

    Decitabine is a hypomethylating agent.It hypomethylates DNA by inhibiting DNA methyltransferase.
  3. DNA methyltransferase inhibitor

    Zebularine (NSC309132; 4-Deoxyuridine) is a DNA methyltransferase inhibitor.
  4. MGMT inhibitor

    Lomeguatrib is a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase.
  5. DNA methyltransferase inhibitor

    RG108 is a non-nucleoside inhibitor of DNA methyltransferase with IC50 of 115 nM.
  6. MGMT inhibitor

    O6-Benzylguanine is an effective substrate and efficient inactivator of DNA alkyltransferase. O6-Benzylguanine is an inhibitor of MGMT.
  7. DNMT inhibitor

    SGI 1027 is a DNMT inhibitor with IC50 of 6, 8, 7.5 uM for DNMT1, DNMT3A, and DNMT3B, respectively.
  8. Sodium channel blocker/DNMT inhibitor

    Procainamide HCl is a sodium channel blocker, and also a DNA methyltransferase inhibitor.
  9. DNMT1 inhibitor

    SW155246 is a potent and selective DNMT1 (DNA methyltransferase 1) inhibitor with IC50 of 1.2 μM. SW155246 induces re-expression of the tumor suppressor geneRASSF1 in A549 cells.

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