GABA Receptors

47 Item(s)

per page

Set Descending Direction
  1. CTP354

    Catalog No. A15939
    Quick View
    GABA(A) modulator
    CTP354 a novel deuterated subtype-selective GABA(A) modulator. Learn More
  2. RWJ-51204

    Catalog No. A12875
    Quick View
    partial agonist of GABA(A) receptor
    RWJ-51204 is a partial agonist of GABA(A) receptor, with Ki of 0.2-2 nM to the benzodiazepine site on GABA(A) receptors. Learn More
  3. TPA 023

    Catalog No. A20140
    Quick View
    GABAA α2/α3 agonist
    TPA 023 is a GABAA α2/α3 subtype-selective agonist, with Ki of 0.19-0.41 nM. Learn More
  4. CP-409092

    Catalog No. A20152
    Quick View
    GABAA receptor partial agonist
    CP-409092 is a partial agonist of GABAA receptor, with anti-anxiety activity. Learn More
  5. Vigabatrin

    Catalog No. A15277
    Quick View
    GABA-transaminase inhibitor
    Vigabatrin is a structural analog of the inhibitory neurotransmitter ??-aminobutyric acid (GABA) that irreversibly inhibits the catabolism of GABA by GABA transaminase. Learn More
  6. MRK-016

    Catalog No. A12046
    Quick View
    GABAA α5 receptor agonist
    MRK-016 is a selective, orally bioavailable inverse agonist of GABAA α5 receptor, with an EC50 of 3 nM for GABAA α5, and Kis of 0.83, 0.85, 0.77?and 1.4?nM for human?GABAA?α1β3γ2, GABAA?α2β3γ2, GABAA?α3β3γ2, and GABAA?α5β3γ2, respectively; MRK-016 also readily penetrates the CNS. Learn More
  7. Piperazine

    Catalog No. A16171
    Quick View
    GABA receptor agonist
    Piperazine is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring. Learn More
  8. Tiagabine hydrochloride

    Catalog No. A16135
    Quick View
    GABA reuptake inhibitor
    Tiagabine is an anti-convulsive medication. The medication is also utilized in the treatment of panic disorder, as are a few other anticonvulsants. Learn More
  9. Picrotoxin

    Catalog No. A14004
    Quick View
    GABAA receptor antagonist
    Picrotoxin is a GABAA receptor antagonist. This compound has been shown to increase noradrenaline levels and turnover in the hypothalamus. Learn More
  10. Tiagabine

    Catalog No. A13198
    Quick View
    GABA reuptake inhibitor
    Tiagabine is a selective gamma-aminobutyric acid (GABA) reuptake inhibitor. Learn More
  11. (-)-Securinine

    Catalog No. A17102
    Quick View
    GABA receptor antagonist
    (-)-Securinine is an alkaloid originally isolated from S. suffructicosa. Securinine, is a specific GABA receptor antagonist and has been found to have significant in vivo CNS activity. Learn More
  12. Zolpidem

    Catalog No. A15288
    Quick View
    Benzodiazepine agonist
    Zolpidem is an inhibitory neurotransmitter, by binding to GABAA receptors at the same location as benzodiazepines. Learn More
  13. Lorediplon

    Catalog No. A13449
    Quick View
    GABAA receptor modulator
    Lorediplon is a novel non-benzodiazepine, hypnotic drug acting as a GABAA receptor modulator, Learn More
  14. U-93631

    Catalog No. A16336
    Quick View
    GABAA receptor ligand
    U-93631 is a GABAA receptor ligand of novel chemical structure with IC50 of 100 nM,and has been shown to induce a rapid, time-dependent decay of GABA-induced whole-cell Cl-currents in recombinant GABAA receptors. Learn More
  15. Bemegride

    Catalog No. A12298
    Quick View
    Bemegride is a central nervous system stimulant and antidote for barbiturate poisoning. Learn More
  16. Bamaluzole

    Catalog No. A17107
    Quick View
    GABA receptor agonist
    Bamaluzole is a GABA receptor agonist. Learn More
  17. Cgp 52432

    Catalog No. A17140
    Quick View
    GABA-A receptor antagonist
    Cgp 52432 is a GABA-A receptor antagonist. Learn More
  18. Afloqualone

    Catalog No. A17276
    Quick View
    GABA receptor agonist
    Afloqualone, also known as HQ-495, is a centrally acting muscle relaxant. Afloqualone inhibits vestibular nystagmus probably due to both inhibition of selective polysynaptic transmission and enhancement of the effects of GABA and glycine in the lateral vestibular nucleus (LVN), and its GABA-enhancing effect is thought to be attributable to the increased sensitivity of GABA receptors of the LVN neuron site. Learn More
  19. Allopregnanolone

    Catalog No. A17782
    Quick View
    GABA(A) receptor modulator
    Brexanolone, also known as 3a5a-Allopregnanolone; Allotetrahydroprogesterone and Allopregnanolone, is a GABA(A) receptor modulator potentially for the treatment of epilepsy and depression. Learn More
  20. Homotaurine

    Catalog No. A17944
    Quick View
    GABA receptor agonist
    Tramiprosate, also known as homotaurine, is a gamma-Aminobutyric acid (GABA) receptor agonist and a glycosaminoglycan mimetic used in the treatment of Alzheimer's disease. Learn More
  21. Baclofen

    Catalog No. A18248
    Quick View
    GABA agonist
    Baclofen is a GABA agonist specific for GABA-B receptors. Baclofen is a synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing It acts at spinal and supraspinal sites, reducing excitatory transmission. Learn More
  22. CGP 36742

    Catalog No. A18666
    Quick View
    GABAB receptor antagonist
    CGP 36742 is a selective GABAB receptor antagonist that can penetrate the blood?Cbrain barrier after peripheral administration, with an IC50 of 32?μM. CGP 36742 is useful in treatment of depression. Learn More
  23. Etifoxine hydrochloride

    Catalog No. A15084
    Quick View
    Anxiolytic anticonvulsant
    Etifoxine hydrochloride is potentiator of GABAA receptor function in cultured neurons. Learn More
  24. Etifoxine

    Catalog No. A15083
    Quick View
    Anxiolytic anticonvulsant
    Etifoxine is potentiator of GABAA receptor function in cultured neurons. Learn More
  25. 4-Aminobutyric acid

    Catalog No. A14934
    Quick View
    4-Aminobutyric acid is the chief inhibitory neurotransmitter in the mammalian central nervous system. Learn More
  26. (+)-Bicuculline

    Catalog No. A12590
    Quick View
    GABAA antagonist
    (+)-Bicuculline is a classical GABAA antagonist. Learn More
  27. Primidone (Mysoline)

    Catalog No. A10754
    Quick View
    Primidone is an anticonvulsant. Potentiates GABAA receptor function. Learn More
  28. Gabapentin Hydrochloride

    Catalog No. A10414
    Quick View
    Gabapentin Hydrochloride is a GABA analogue. Learn More
  29. Gabapentin

    Catalog No. A10413
    Quick View
    Gabapentin (Neurontin) is a pharmaceutical agent, specifically a GABA analogue. Learn More
  30. Furosemide

    Catalog No. A10412
    Quick View
    Furosemide is a non-competitive antagonist at GABAA receptors with ~ 100-fold greater selectivity for α6-containing receptors than α1-containing receptors. Learn More
  31. Flumazenil

    Catalog No. A10397
    Quick View
    Benzodiazepine antagonist
    Flumazenil, an imidazobenzodiazepine derivative, antagonizes the actions of benzodiazepines on the central nervous system. Flumazenil competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine receptor complex. Flumazenil is a weak partial agonist in some animal models of activity, but has little or no agonist activity in humans. Learn More
  32. SKF 89976A HCl

    Catalog No. A10849
    Quick View
    GABA uptake inhibitor
    SKF 89976A hydrochloride is a potent inhibitor of GABA uptake with IC50 of 0.13, 550, 944 and 7210 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively. Learn More
  33. Nefiracetam (Translon)

    Catalog No. A10631
    Quick View
    Nefiracetam is cognitive enhancer. It activates L/N-type calcium channels, cholinergic, monoaminergic and GABAergic systems. Learn More
  34. Baicalin

    Catalog No. A10121
    Quick View
    HIV-1 production Inhibitor
    Baicalin is a known prolyl endopeptidase inhibitor and affects the GABA receptors. Learn More
  35. Zaleplon

    Catalog No. A12993
    Quick View
    Zaleplon is a non-benzodiazepine agent that acts as an agonist at the benzodiazepine site. Learn More
  36. AWD 131-138

    Catalog No. A13726
    Quick View
    GABAA receptor agonist
    AWD 131-138 is a new low-affinity partial benzodiazepine receptor agonist with potent anticonvulsant and anxiolytic properties in rodent models. Learn More
  37. 2-Hydroxysaclofen

    Catalog No. A13696
    Quick View
    GABAB receptors antagonist
    2-Hydroxysaclofen is a potent and selective antagonist at GABAB receptors. Learn More
  38. Muscimol hydrobromide

    Catalog No. A13459
    Quick View
    GABA(A) receptor agonist
    Muscimol hydrobromide is a potent but toxic structural analog of g-aminobutyric acid (GABA), with a zwitterionic structure. Learn More
  39. Muscimol

    Catalog No. A14005
    GABAA/GABAC agonist
    Muscimol is a full GABAA agonist and partial GABAC agonist. It binds GABAA on both high- and low-affinity sites (Kd = 10 and 270 nM, respectively), stimulating chloride efflux with an EC50 value of 200 nM. Learn More
  40. Guvacine hydrochloride

    Catalog No. A13613
    Quick View
    GABA uptake inhibitor
    Guvacine hydrochloride inhibits GABA uptake (IC50 values are 14, 58, 119 and 1870 uM for hGABA T-1, rGABA T-2, hGABA T-3 and hBGT-1 respectively). Learn More
  41. Indiplon

    Catalog No. A13769
    Quick View
    GABAA receptor modulator
    Indiplon is a pyrazolopyrimidine that acts as a high-affinity positive allosteric modulator of the GABAA receptor, potentiating GABA-activated chloride currents in a dose-dependent and reversible manner. Learn More
  42. RO 15-3890

    Catalog No. A14349
    Quick View
    benzodiazepine receptor antagonist
    Ro 15-1788 is a benzodiazepine receptor antagonist. Learn More
  43. a5IA

    Catalog No. A14343
    Quick View
    Benzodiazepine agonist
    a5IA is a nootropic drug invented in 2004 by a team working for Merck, Sharp and Dohme, which acts as a subtype-selective inverse agonist at the benzodiazepine binding site on the GABAA receptor. Learn More
  44. Cloflubicyne

    Catalog No. A13932
    Quick View
    GABA antagonist
    Cloflubicyne is a potent non-competitive GABA antagonist, convulsant, laboratory insecticide. Learn More
  45. Oxiracetam

    Catalog No. A14281
    Quick View
    Oxiracetam is a cyclic derivative of gamma-aminobutyric acid (GABA). Learn More
  46. Bretazenil

    Catalog No. A13784
    Quick View
    GABAA agonist
    Bretazenil, a benzodiazepine receptor partial agonist, as an adjunct in the prophylactic treatment of OP poisoning. Learn More
  47. Dihydromyricetin (Ampeloptin)

    Catalog No. A10252
    Quick View
    Dihydropyrimidinase Inhibitor
    Dihydromyricetin (Ampelopsin (flavanol); Ampeloptin) is a natural antioxidant with good prospects. Learn More

47 Item(s)

per page

Set Descending Direction