HMG-CoA Reductase

Catalog No.Inhibitor Name HMG-CoA Reductase
A10810Rosuvastatin Calcium
**
A11877Lovastatin
***
A11912Pravastatin sodium
**
A11184Clinofibrate
*
A11800Atorvastatin Calcium
A13709Mevastatin

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Clinofibrate

    Catalog No. A11184
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    HMG-CoA Reductase inhibitor

    Clinofibrate is a lipid clearing agent that appears to modify lipid metabolism, diminishing the steroid induced accumulation of lipids within osteocytes. It also can effectively reduce the plasma fibrinogen level.

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  2. Fluvastatin sodium

    Catalog No. A10403
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    HMG-CoA reductase inhibitor
    Fluvastatin sodium (XU 62320) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Learn More
  3. Simvastatin

    Catalog No. A10845
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    HMG-CoA reductase inhibitor
    Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM. Learn More
  4. 2-Hydroxy atorvastatin calcium salt

    Catalog No. A18971
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    HMG-CoA reductase inhibitor
    2-Hydroxy atorvastatin calcium salt is a hydroxy metabolite of Atorvastatin calcium salt. Atorvastatin is a potent HMG-CoA reductase inhibitor with an IC50 value of 8 nM. Learn More
  5. Fluvastatin

    Catalog No. A21232
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    HMG-CoA reductase inhibitor
    Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Learn More
  6. Rosuvastatin

    Catalog No. A11122
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    HMG-CoA reductase inhibitor
    Rosuvastatin is a member of the drug class of statins, used to treat high cholesterol and related conditions, and to prevent cardiovascular disease. Learn More
  7. Pitavastatin calcium (Livalo)

    Catalog No. A10737
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    HMG-CoA reductase inhibitor
    Pitavastatin Calcium is a competitive inhibitor of the enzyme HMGCR (HMG-CoA reductase) results in a reduction in LDL cholesterol synthesis. Learn More
  8. Rosuvastatin calcium (Crestor)

    Catalog No. A10810
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    HMG-CoA reductase inhibitor
    Rosuvastatin (Crestor) is a member of the drug class of statins, used to treat high cholesterol and related conditions, and to prevent cardiovascular disease. Rosuvastatin is a competitive inhibitor of the enzyme HMG-CoA reductase, having a mechanism of action similar to that of other statins. Learn More
  9. Pravastatin sodium

    Catalog No. A11912
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    HMG-CoA reductase inhibitor
    Pravastatin sodium is a water-soluble, competitive inhibitor of 3-hydroxy-3-methyl coenzyme A (HMG-CoA) reductase. Potently blocks cholesterol synthesis in vivo (Ki~ 1 nM) and displays cardioprotective properties. Learn More
  10. Pitavastatin Lactone

    Catalog No. A13896
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    HMG-CoA reductase inhibitor
    Pitavastatin Lactone is an HMG-CoA reductase inhibitor. Learn More
  11. Atorvastatin

    Catalog No. A13743
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    HMG-CoA reductase inhibitor
    Atorvastatin is an HMG-CoA reductase inhibitor (IC50 = 154 nM) that is effective in treating hypercholesterolemia and certain dyslipidemias. Learn More
  12. Mevastatin

    Catalog No. A13709
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    HMG-CoA reductase inhibitor
    Mevastatin is an inhibitor of HMG-CoA reductase. Learn More
  13. Atorvastatin calcium

    Catalog No. A11800
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    HMG-CoA reductase inhibitor
    Atorvastatin (Lipitor) is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol. Learn More
  14. Lovastatin (Mevacor)

    Catalog No. A11877
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    HMG-CoA reductase inhibitor
    Lovastatin is an inhibitor of HMG-CoA reductase with IC50 of 3.4 nM, used for lowering cholesterol (hypolipidemic agent). Learn More
  15. Swertiamarin

    Catalog No. A12128
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    HMG-CoA reductase inhibitor
    Swertiamarin has shown potential as antiatherogenic agent by inhibiting HMG-CoA reductase activity in high cholesterol fed rats. Learn More

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