HMG-CoA Reductase

Catalog No.Inhibitor Name HMG-CoA Reductase
A10810Rosuvastatin Calcium
**
A11877Lovastatin
***
A11912Pravastatin sodium
**
A11184Clinofibrate
*
A11800Atorvastatin Calcium
A13709Mevastatin

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Rosuvastatin calcium (Crestor)

    Catalog No. A10810
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    HMG-CoA reductase inhibitor
    Rosuvastatin (Crestor) is a member of the drug class of statins, used to treat high cholesterol and related conditions, and to prevent cardiovascular disease. Rosuvastatin is a competitive inhibitor of the enzyme HMG-CoA reductase, having a mechanism of action similar to that of other statins. Learn More
  2. Pravastatin sodium

    Catalog No. A11912
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    HMG-CoA reductase inhibitor
    Pravastatin sodium is a water-soluble, competitive inhibitor of 3-hydroxy-3-methyl coenzyme A (HMG-CoA) reductase. Potently blocks cholesterol synthesis in vivo (Ki~ 1 nM) and displays cardioprotective properties. Learn More
  3. Atorvastatin calcium

    Catalog No. A11800
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    HMG-CoA reductase inhibitor
    Atorvastatin (Lipitor) is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol. Learn More
  4. Pitavastatin calcium (Livalo)

    Catalog No. A10737
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    HMG-CoA reductase inhibitor
    Pitavastatin Calcium is a competitive inhibitor of the enzyme HMGCR (HMG-CoA reductase) results in a reduction in LDL cholesterol synthesis. Learn More
  5. Lovastatin (Mevacor)

    Catalog No. A11877
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    HMG-CoA reductase inhibitor
    Lovastatin is an inhibitor of HMG-CoA reductase with IC50 of 3.4 nM, used for lowering cholesterol (hypolipidemic agent). Learn More
  6. Swertiamarin

    Catalog No. A12128
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    HMG-CoA reductase inhibitor
    Swertiamarin has shown potential as antiatherogenic agent by inhibiting HMG-CoA reductase activity in high cholesterol fed rats. Learn More
  7. Mevastatin

    Catalog No. A13709
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    HMG-CoA reductase inhibitor
    Mevastatin is an inhibitor of HMG-CoA reductase. Learn More
  8. Atorvastatin

    Catalog No. A13743
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    HMG-CoA reductase inhibitor
    Atorvastatin is an HMG-CoA reductase inhibitor (IC50 = 154 nM) that is effective in treating hypercholesterolemia and certain dyslipidemias. Learn More
  9. Pitavastatin Lactone

    Catalog No. A13896
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    HMG-CoA reductase inhibitor
    Pitavastatin Lactone is an HMG-CoA reductase inhibitor. Learn More

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