Others

Acitazanolast is an active metabolite of tazanolast and anti-allergic drug.

Azalomycin-B is a macrolide antibiotic produced by Streptomyces hygroscopicus.

Gynostemma Extract is a saponins extract derived from the Gynostemma pentaphyllum. The increase of SGOT, SGPT activities in CCl4 liver injury were significantly reduced by treatment with Gypenoside. It also elevated the A/G ratio.

Nanchangmycin (dianemycin) is a polyether antibiotic with similar structure to dianemycin and is very active against a broad spectrum of harmful nematodes and insects but not for for mammals and plants.

Pentagastrin (trade name Peptavlon) is a synthetic polypeptide that has effects like gastrin when given parenterally.[1] It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid as the pentagastrin-stimulated calcitonin test.

Risedronate sodium is a bisphosphonate used to strengthen bone, treat or prevent osteoporosis, and treat Paget's disease of bone.

Isoindigotin is a potential antileukemic agent.

Indacaterol is an ultra-long-acting beta-adrenoceptor agonist.

P005672 is a phase II drug for antibacterial/anti-inflammatory acne treatment.

Calcipotriol hydrate is the hydrate form of vitamin D3 that displays minimal effects on calcium homeostasis.

Cot inhibitor-1 is a COT/Tpl2 inhibitor.

Salmefamol is useful for treatment of respiratory diseases

Isepamicin (also Isepamycin) is an aminoglycoside antibiotic.

Telithromycin is a ketolide antibiotic. It is used to treat community acquired pneumonia of mild to moderate severity. Telithromycin prevents bacteria from growing, by interfering with their protein synthesis. Telithromycin binds to the subunit 50S of the bacterial ribosome, and blocks the progression of the growing polypeptide chain.

ENOblock (AP-III-a4) is a novel small molecule which is the first, nonsubstrate analogue that directly binds to enolase and inhibits its activity (IC50=0.576 uM); inhibit cancer cell metastasis in vivo.

PK14105 is a biological evaluation as a potential radioligand for PET studies of PBBS receptors.

N-563 is an analogue of deoxyspergualin with an immunostimulating activity,it promotes resistance to Candida albicans infection in mice.

3-arylisoquinolinamine derivative is a 3-arylisoquinolinamine derivative with antitumor activity.

LR-90 is an advanced glycation end product (AGE) inhibitor, inhibits inflammatory responses in human monocytes. LR-90 is also used in the research of diabetic animal model.

CHIR-090 is a potent, slow, tight-binding inhibitor of the LpxC deacetylase. It binds to E. coli LpxC with a Ki of 4.0 nM.

Stiripentol is an epilepsy drug. It has been used as co-therapy for treatment of epilepsy

ANX-510 is a folate-based biomodulator with potential antineoplastic activity. 5,10-methylenetetrahydrofolate (MTHF) stabilizes the covalent binding of the fluorouracil metabolite 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (FdUMP) to its target enzyme, thymidylate synthase, which results in inhibition of thymidylate synthase, depletion of thymidine triphosphate (TTP), a necessary constituent of DNA, and tumor cell death. Unlike leucovorin, MTHF, as the active form of folate, does not require metabolic activation and may increase the chemotherapeutic effects of fluorouracil with lower toxicity.

N/A

Pirozadil is a hypolipidemic agent.

Tepilamide fumarate (XP-23829) is an oral fumaric acid ester, acts as a prodrug of monomethyl fumarate, and is used in the research of moderate to severe chronic plaque psoriasis.

Parimifasor (LYC30937) is an immunomodulator, with anti-inflammatory activity.

BIO-32546 is a novel modulator of the activity of the autotaxin (ATX) enzyme

Carebastine is the active carboxylic acid metabolite of Ebastine.

Telavancin is a semi-synthetic vancomycin analogue prepared by the addition of a decylaminoethyl moiety to the free amino group of the disaccharide.

S107 is a RyR-selective 1,4-benzothiazepine derivative that stabilizes RyR2 channels by enhancing the binding affinity of calstabin2 to mutant and/or PKA-phosphorylated channels.

TD-198946, a thienoindazole derivative, is a potent chondrogenic agent.

Tirapazamine is a bioreductive, anti-neoplastic, anti-cancer agent that is selectively toxic to cells under hypoxic conditions.

Ibutamoren, also known as MK-677 (L-163,191), is a drug which acts as a potent, orally active growth hormone secretagogue, mimicking the GH stimulating action of the endogenous hormone ghrelin.

Tafenoquine is an 8-aminoquinoline drug manufactured by GlaxoSmithKline that is being investigated as a potential treatment for malaria, as well as for malaria prevention.

Ciliobrevin D is the first specific small molecule antagonist of cytoplasmic dynein

Ac-Gly-BoroPro is a selective FAP inhibitor with a Ki of 23 nM.

Glycolic acid oxidase inhibitor 1 is a glycolate oxidase inhibitor, extracted from patent EP0021228A1, in Table IV.

Ioversol is low osmolality, nonionic, radiographic contrast agent.

Amsilarotene (TAC-101) is a retinobenzoic acid with potential antineoplastic activity.

Atrimustine is a conjugate of chlorambucil and β-estradiol benzoate with the antitumor activity.

MGL-3196 is an orally small-molecule liver-directed thyroid hormone receptor agonist designed to increase cholesterol uptake into the liver and increase its metabolism.

Pyrroloquinoline quinone is a cofactor of microbial quinoprotein enzyme, and imidazopyrroline. A redox/cofactor found in a a class of enzymes called quinoproteins.

Azacosterol acts as an inhibitor of 24-dehydrocholesterol reductase (24-DHCR), preventing the formation of cholesterol from desmosterol.

Ruzadolane (UP 26-91) is a non-narcotic, centrally-acting analgesic agent.

Shows antimalerial activity with IC50 values of 11.2 nM for 3D7 strain, 12.6 nM for HB3 strain, 17.6 nM for K1 strain

Golotimod is an orally bioavailable synthetic peptide containing the amino acids D-glutamine and L-tryptophan connected by a gamma-glutamyl linkage with potential immunostimulating, antimicrobial and antineoplastic activities.

3,4-Dehydro Cilostazol is a metabolite of Cilostazol.