Catalog No.Inhibitor Name PERKOther
A13816ISRIB (trans-isomer)

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2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. GSK2606414

    Catalog No. A12792
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    PERK inhibitor
    GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM. Learn More
  2. GSK2656157

    Catalog No. A13577
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    PERK Inhibitor
    GSK2656157 is an ATP-competitive inhibitor of PERK enzyme activity with an IC(50) of 0.9 nmol/L. It is highly selective for PERK with IC(50) values >100 nmol/L against a panel of 300 kinases. Learn More
  3. ISRIB (trans-isomer)

    Catalog No. A13816
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    PERK inhibitor
    ISRIB (trans-isomer) is a potent and selective small molecule inhibitor of PERK signaling (IC50 ~5 nM) that can potently reverse the effects of eIF2α phosphorylation. Learn More
  4. Salubrinal

    Catalog No. A12676
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    eIF2α dephosphorylation inhibitor
    Salubrinal is a cell-permeable, selective inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Protects cells from endoplasmic reticulum stress-induced apoptosis (EC50 ~ 15 μM). Learn More
  5. ISRIB

    Catalog No. A14302
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    PERK inhibitor
    ISRIB, the trans-isomer of ISRIB, is a potent and selective PERK inhibitor with IC50 of 5 nM. Learn More
  6. Azoramide

    Catalog No. A16075
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    UPR modulator
    Azoramide is a small-molecule modulator of the unfolded protein response with antidiabetic activity. Learn More

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