PERK

Catalog No.Inhibitor Name PERKOther
A12792GSK2606414
****
EIF2AK1 (HRI),EIF2AK2 (PKR)
A13577GSK2656157
***
A13816ISRIB (trans-isomer)
**
A12676Salubrinal

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. GSK2606414

    Catalog No. A12792
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    PERK inhibitor
    GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM. Learn More
  2. GSK2656157

    Catalog No. A13577
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    PERK Inhibitor
    GSK2656157 is an ATP-competitive inhibitor of PERK enzyme activity with an IC(50) of 0.9 nmol/L. It is highly selective for PERK with IC(50) values >100 nmol/L against a panel of 300 kinases. Learn More
  3. ISRIB (trans-isomer)

    Catalog No. A13816
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    PERK inhibitor
    ISRIB (trans-isomer) is a potent and selective small molecule inhibitor of PERK signaling (IC50 ~5 nM) that can potently reverse the effects of eIF2α phosphorylation. Learn More
  4. Salubrinal

    Catalog No. A12676
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    eIF2α dephosphorylation inhibitor
    Salubrinal is a cell-permeable, selective inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Protects cells from endoplasmic reticulum stress-induced apoptosis (EC50 ~ 15 μM). Learn More
  5. ISRIB

    Catalog No. A14302
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    PERK inhibitor
    ISRIB, the trans-isomer of ISRIB, is a potent and selective PERK inhibitor with IC50 of 5 nM. Learn More
  6. Azoramide

    Catalog No. A16075
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    UPR modulator
    Azoramide is a small-molecule modulator of the unfolded protein response with antidiabetic activity. Learn More

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