PERK
Catalog No. | Inhibitor Name | PERK | Other |
---|---|---|---|
A12792 | GSK2606414 | **** | EIF2AK1 (HRI),EIF2AK2 (PKR) |
A13577 | GSK2656157 | *** | |
A13816 | ISRIB (trans-isomer) | ** | |
A12676 | Salubrinal |
Notes:
1.Hover mouse over " " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
-
Salubrinal
Catalog No. A12676 eIF2α dephosphorylation inhibitorSalubrinal is a cell-permeable, selective inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Protects cells from endoplasmic reticulum stress-induced apoptosis (EC50 ~ 15 μM). Learn More -
GSK2606414
Catalog No. A12792 PERK inhibitorGSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM. Learn More -
GSK2656157
Catalog No. A13577 PERK InhibitorGSK2656157 is an ATP-competitive inhibitor of PERK enzyme activity with an IC(50) of 0.9 nmol/L. It is highly selective for PERK with IC(50) values >100 nmol/L against a panel of 300 kinases. Learn More -
ISRIB (trans-isomer)
Catalog No. A13816 PERK inhibitorISRIB (trans-isomer) is a potent and selective small molecule inhibitor of PERK signaling (IC50 ~5 nM) that can potently reverse the effects of eIF2α phosphorylation. Learn More -
ISRIB
Catalog No. A14302 PERK inhibitorISRIB is a potent and selective PERK inhibitor with IC50 of 5 nM. Learn More -
Azoramide
Catalog No. A16075 UPR modulatorAzoramide is a small-molecule modulator of the unfolded protein response with antidiabetic activity. Learn More -
CCT020312
Catalog No. A19137 EIF2AK3/PERK activatorCCT020312 is a selective EIF2AK3/PERK activator. CCT020312 elicits EIF2A phosphorylation in cells. Learn More