Shop By
Catalog No.
Product Name
Application
Product Information
Product Citation
-
Syk Inhibitor
R406 is an orally available spleen tyrosine kinase inhibitor with an IC50 of 41 nM. -
Syk Inhibitor
BAY 61-3606 is a cell-permeable imidazopyrimidine compound that acts as a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src.- So-Jeong Park, .et al. , Ecotoxicol Environ Saf, 2023, Jul 15;260:115061 PMID: 37257343
- Ami Kobayashi, .et al. , Nat Commun, 2023, Jan 25;14(1):312 PMID: 36697396
- Ju-Won Jang, .et al. , Int Immunopharmacol, 2021, Mar 21;95:107509 PMID: 33761438
- Sojin Park, .et al. , Sci Rep, 2020, 10: 11784 PMID: 32678160
- Park S, .et al. , Free Radic Res, 2018, Sep 11:1-11 PMID: 30203714
-
Syk inhibitor
P505-15 (also known as PRT062607) is a novel, highly selective, and orally bioavailable small molecule SYK inhibitor (SYK IC(50) = 1 nM) with anti-SYK activity that is at least 80-fold greater than its affinity for other kinases.- Li T, .et al. , Oncogene, 2018, Nov;37(47):6180-6194 PMID: 30013190
-
SYK inhibitor
Lanraplenib (GS-9876) is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases. -
Dual Syk and JAK inhibitor
PRT062070 is a novel, oral, dual spleen tyrosine kinase (Syk) and janus kinase (JAK) inhibitor. Cerdulatinib preferentially inhibited JAK1 and JAK3 dependent cytokine mediated signaling and functional responses in various cell types. -
Syk Inhibitor
BAY 61-3606 is a potent (Ki = 7.5 nM) and selective inhibitor of Syk kinase. -
Syk inhibitor
PRT-060318 is a novel selective inhibitor of the tyrosine kinase Syk, as an approach to HIT treatment.