Name: CCG-222740
SKU: A22348
Price: 315 USD
Rating: 5 (288 reviews)

Catalog No.

Product Name

Application

Product Information

Product Citation

A12972

KRas G12C inhibitor 4

KRas G12C inhibitor

KRas G12C inhibitor 1 is a compound that inhibits KRas G12C, extracted from patent US 20180072723 A1.

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A13018

KRas G12C inhibitor 3

Kras-G12C inhibitor

KRas G12C inhibitor 3 is a compound that inhibits KRas G12C, extracted from patent US 20180072723 A1.

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A13064

KRas G12C inhibitor 2

Kras-G12C inhibitor

KRas G12C inhibitor 2 is a compound that inhibits KRas G12C, extracted from patent US 20180072723 A1.

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A13112

GGTI-2418

GGTase inhibitor

GGTI-2418 is a synthetic peptidomimetic inhibitor of geranylgeranyltransferase I (GGTase I) that appears to induce apoptosis by downregulating several pivotal oncogenic and tumor survival pathways.

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A13152

KRas G12C inhibitor 1

Kras-G12C inhibitor 1

KRas G12C inhibitor 1 is a compound that inhibits KRas G12C, extracted from patent US 20180072723 A1.

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A18441

KRAS G12C inhibitor 17

KRAS G12C inhibitor

KRAS G12C inhibitor 17 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 82, has an IC50 of 5 nM.

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A18444

KRAS G12C inhibitor 16

KRAS G12C inhibitor

KRAS G12C inhibitor 16 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 39, has an IC50 of 97 nM.

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A18447

KRAS G12C inhibitor 15

KRAS G12C inhibitor

KRAS G12C inhibitor 15 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 22, has an IC50 of 5 nM.

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A18473

PHT-7.3

Cnk1 inhibitor

PHT-7.3 is a selective inhibitor of connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain, which inhibits mut-KRas, but not wild-type KRas cancer cell and tumor growth and signaling.

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A18840

KRAS G12C inhibitor 5

KRas G12C inhibitor

KRAS G12C inhibitor 5 is a KRas G12C inhibitor extracted from patent WO2017201161A1, Compound example 147.

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A19041

KRAS G12C inhibitor 13

KRAS G12C inhibitor

KRAS G12C inhibitor 13 is a KRAS G12C inhibitor extracted from patent WO2018143315A1, compound 30.

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A19890

EPAC 5376753

Epac inhibitor

EPAC 5376753 is an allosterically inhibitor of Epac which inhibits Epac1 with an IC50 of 4 ?M in Swiss 3T3 cells.

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A21358

(R)-CE3F4

exchange protein inhibitor

(R)-CE3F4 is a potent and selective inhibitor of exchange protein directly activated by cAMP isoform 1 (Epac1), with an IC50 of 4.2 μM, with 10-fold selectivity for Epac1 over Epac2 (IC50, 44 μM).

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A21504

Rhosin

RhoA subfamily Rho GTPases inhibitor

Rhosin is a potent, specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction with a Kd of ~ 0.4 uM, and does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin induces cell apoptosis.

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A21648

Rhosin hydrochloride

RhoA subfamily Rho GTPases inhibitor

Rhosin hydrochloride is a potent, specific RhoA subfamily Rho GTPases inhibitor.

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A21689

(Rac)-Antineoplaston A10

Ras inhibitor

(rac)-Antineoplaston A10 is the racemate of Antineoplaston A10. Antineoplaston A10 is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer.

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A22285

MLS000532223

Rho family GTPases inhibitor

MLS000532223 is a high affinity, selective inhibitor of Rho family GTPases, with EC50 values ranging from 16 μM to 120 μM.

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A22348

CCG-222740

MRTF pathway inhibitor

CCG-222740 is an orally active and selective Rho/myocardin-related transcription factor (MRTF) pathway inhibitor. CCG-222740 is also a potent inhibitor of alpha-smooth muscle actin protein expression.

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Ras