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KPT185
Catalog No. A12975 CRM1 InhibitorKPT185 is a selective CRM1 inhibitor. KPT-185 significantly inhibits leukemia cell proliferation with IC50 ranging from 100 nM to 500 nM, and induces cell-cycle arrest and apoptosis of AML cell lines and primary AML blasts. Learn More -
Selinexor (KPT-330)
Catalog No. A12582 CRM1 inhibitorKPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia. Learn More -
Piperlongumine
Catalog No. A14124 TrxR1/CRM1 inhibitorPiperlongumine selectively kills cancer cells regardless of p53 status without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1). Learn More -
KPT 335
Catalog No. A16078 SINE inhibitorKPT 335 is an orally bioavailable Selective Inhibitor of Nuclear Export (SINE). Learn More -
KPT276
Catalog No. A16341 SINE/CRM1 inhibitorKPT276, analog of KPT-185, is a selective inhibitor of nuclear export (SINE) and CRM1. Learn More -
Eltanexor Z-isomer
Catalog No. A21786 CRM1 inhibitorEltanexor Z-isomer (KPT-8602 Z-isomer) is the less active isomer of KPT-8602. KPT-8602 is a potent CRM1 inhibitor. Learn More -
Leptomycin B
Catalog No. A20985 nuclear export receptor CRM1 inhibitorLeptomycin B (CI 940; LMB) is a potent inhibitor of the nuclear export of proteins. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Leptomycin B is a potent antifungal antibiotic blocking the eukaryotic cell cycle. Learn More
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