CRM1

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  1. KPT185

    Catalog No. A12975
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    CRM1 Inhibitor
    KPT185 is a selective CRM1 inhibitor. KPT-185 significantly inhibits leukemia cell proliferation with IC50 ranging from 100 nM to 500 nM, and induces cell-cycle arrest and apoptosis of AML cell lines and primary AML blasts. Learn More
  2. KPT-330

    Catalog No. A12582
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    CRM1 inhibitor
    KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia. Learn More
  3. Piperlongumine

    Catalog No. A14124
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    TrxR1/CRM1 inhibitor
    Piperlongumine selectively kills cancer cells regardless of p53 status without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1). Learn More
  4. KPT 335

    Catalog No. A16078
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    SINE inhibitor
    KPT 335 is an orally bioavailable Selective Inhibitor of Nuclear Export (SINE). Learn More
  5. KPT276

    Catalog No. A16341
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    SINE/CRM1 inhibitor
    KPT276, analog of KPT-185, is a selective inhibitor of nuclear export (SINE) and CRM1. Learn More
  6. Eltanexor Z-isomer

    Catalog No. A21786
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    CRM1 inhibitor
    Eltanexor Z-isomer (KPT-8602 Z-isomer) is the less active isomer of KPT-8602. KPT-8602 is a potent CRM1 inhibitor. Learn More
  7. Leptomycin B

    Catalog No. A20985
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    nuclear export receptor CRM1 inhibitor
    Leptomycin B (CI 940; LMB) is a potent inhibitor of the nuclear export of proteins. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Leptomycin B is a potent antifungal antibiotic blocking the eukaryotic cell cycle. Learn More

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