Microtubule/Tubulin

Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.

Epothilone B is a macrolide that causes the formation of bundles of intracellular microtubules in non-mitotic cells, induces the formation of hyperstable tubulin polymers, and arrests cell cycling in mitosis.

Podophyllotoxin is a potent inhibitor of microtubule assembly that binds at the colchicine site of tubulin.

Vincristine is a mitotic inhibitor, and is used in cancer chemotherapy.

Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy.

Vincristine is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM.

Nocodazole is a microtubule inhibitor; inhibits mitosis. Also inhibits autophagosome-lysosome fusion.

INH6 is a potent Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction and causes chromosome mis-alignment.

Vinorelbine Tartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin.

Docetaxel trihydrate, an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules.

TRx 0237 (LMT) mesylate is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.

Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC50 of 8.79?nM, and exhibits a broad-spectrum anthelmintic activity.