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Product Information
Product Citation
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P2X3 and P2X2/3 receptor antagonist
A-317491 sodium salt hydrate is a non-nucleotide P2X3 and P2X2/3 receptor antagonist, which inhibits calcium flux mediated by the receptors. -
P2X7 receptor antagonist
A-438079 HCl is a competitive P2X7 receptor antagonist (pIC50 = 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line). Devoid of activity at other P2 receptors (IC50 >> 10 uM). -
P2X7 receptor antagonist
A 438079 Hcl is a competitive P2X7 receptor antagonist (pIC50 = 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line).- Zhihua Yi, .et al. , Front Pharmacol, 2018, 9: 593 PMID: 29950989
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P2X3R antagonist
Gefapixant is an orally active P2X3 receptor (P2X3R) antagonist with IC50s of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. -
purinergic P2X2/3 receptors antagonist
Minodronic acid (YM-529) is an antagonist of purinergic P2X2/3 receptors involved in pain.
