Opioid Receptors

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  1. AR-M 1000390 hydrochloride

    Catalog No. A21911
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    δ opioid receptor agonist
    AR-M 1000390 hydrochloride is an exceptionally selective, potent δ opioid receptor agonist with an EC50 of 7.2??0.9 nM for δ agonist potency. Learn More
  2. Eluxadoline

    Catalog No. A14085
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    opioid receptor agonist
    Eluxadoline is a novel, orally-active drug approved for the treatment of diarrhea and abdominal pain in individuals with diarrhea-predominant irritable bowel syndrome (IBS-D). Learn More
  3. Methylnaltrexone Bromide

    Catalog No. A15159
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    μ-opioid antagonist
    Methylnaltrexone Bromide is a pheriphally-acting µ-opioid antagonist that acts on the gastrointestinal tract to decrease opioid-induced constipation. Learn More
  4. LY2795050

    Catalog No. A15149
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    k-opioid receptor antagonist
    LY2795050 is a novel selective κ-opioid Receptor (KOR) antagonist (IC50=0.72 nM) and has the potential as a PET tracer to image KOR in vivo. Learn More
  5. TRV130 HCl (Oliceridine)

    Catalog No. A15444
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    µ- opioid receptor agonist
    TRV 130 HCl is a novel μ-opioid receptor (MOR) G protein-biased ligand; elicits robust G protein signaling(pEC50=8.1), with potency and efficacy similar to morphine, but with far less beta-arrestin recruitment and receptor internalization. Learn More
  6. GSK1521498 free base

    Catalog No. A18994
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    μ-opioid receptor antagonist
    GSK1521498 free base is a potent and selective μ-opioid receptor (MOR) antagonist. GSK1521498 free base is being used for the treatment of disorders of compulsive consumption of food, alcohol, and drugs. Learn More
  7. GSK1521498 free base (hydrochloride)

    Catalog No. A21792
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    μ-opioid receptor (MOR) antagonist
    GSK1521498 free base (hydrochloride) is a potent and selective μ-opioid receptor (MOR) antagonist. Learn More
  8. DPI-3290

    Catalog No. A13699
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    opioid receptors agonist
    DPI-3290 (Org 41793) is a potent and specific opioid receptors agonist with Ki values of 0.18 nM, 0.46 nM, and 0.62 nM for δ-, μ-, and κ-opioid receptors, respectively. Learn More
  9. CYT-1010 hydrochloride

    Catalog No. A21348
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    mu-opioid receptor agonist
    CYT-1010 hydrochloride is a mu-opioid receptor agonist extracted from patent WO2013173730A2, with EC50s of 13.1 nM and 0.0053 nM on beta-arrestin recruitment and inhibition of cAMP production, respectively. Learn More
  10. JDTic

    Catalog No. A11468
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    κ-opioid receptor antagonist
    JDTic is a highly selective antagonist for the κ-opioid receptor; without affecting the μ- or δ-opioid receptors. Learn More
  11. BTRX-335140

    Catalog No. A18583
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    κ opioid receptor antagonist
    BTRX-335140 (CYM-53093) is a potent and selective, orally active κ opioid receptor (KOR) antagonist, has antagonist activity for κOR, μOR and δOR with IC50 values of 0.8 nM, 110 nM, and 6500 nM, respectively. Learn More
  12. Naloxegol Oxalate

    Catalog No. A15972
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    Opioid antagonist
    Naloxegol is a peripherally-selective opioid antagonist for the treatment of opioid-induced constipation. Learn More
  13. Docusate Sodium

    Catalog No. A16155
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    Docusate Sodium is a laxative used to treat constipation, for constipation due to the use of opiates it maybe used with a stimulant laxative, can be taken by mouth or rectally. Learn More
  14. Cebranopadol (GRT-6005)

    Catalog No. A12670
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    Opioid Receptor Agonist
    Cebranopadol is a potent nociceptin/orphanin FQ peptide (NOP) and opioid receptor agonist Learn More
  15. Trimebutine maleate

    Catalog No. A18115
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    µ- opioid receptor agonist
    Trimebutine Maleate is a drug with antimuscarinic and weak mu opioid agonist effects. Trimebutine Maleate modulates the calcium and potassium channels, relieves abdominal pain in patients with irritable bowel syndrome. Learn More
  16. Bevenopran

    Catalog No. A17110
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    opioid receptor antagonis
    Bevenopran, also known as CB-5945, ADL-5945, MK-2402, OpRA III, is a peripherally selective μ- and δ-opioid receptor antagonist. Learn More
  17. Alvimopan monohydrate

    Catalog No. A14992
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    µ-opioid receptor agonist
    Alvimopan monohydrate is a peripherally acting mu-opioid receptor (PAM-OR, IC50= 1.7 nM) antagonist for accelerating gastrointestinal recovery after surgery. Learn More
  18. JTC-801

    Catalog No. A11076
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    Opioid Receptor antagonist
    JTC-801 is a selective antagonist for the nociceptin receptor, also known as the ORL-1 receptor. Learn More
  19. MCOPPB 3HCl

    Catalog No. A10561
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    NOP receptor agonist
    MCOPPB is a compound which acts as a potent and selective agonist for the nociceptin receptor, with a pKi of 10.07. Learn More
  20. BRL 52537 HCl

    Catalog No. A11210
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    Opioid Receptors agonist
    BRL 52537 hydrochloride is a highly selective and potent κ-opioid agonist (Ki = 0.24 nM). 25 times more potent than morphine. Learn More
  21. Alvimopan (ADL 8-2698)

    Catalog No. A11292
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    Opioid antagonist
    Alvimopan behaves as a peripherally acting μ-opioid antagonist. Alvimopan competitively binds to mu-opioid receptor in the gastrointestinal tract. Learn More
  22. BAN ORL 24

    Catalog No. A11322
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    NOP antagonist
    BAN ORL 24 is a potent and selective NOP receptor antagonist. Learn More
  23. Trimebutine

    Catalog No. A11718
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    Trimebutine is a drug with antimuscarinic and weak mu opioid agonist effects. Learn More
  24. Nalfurafine hydrochloride

    Catalog No. A12579
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    opioid κ-selective agonist
    Nalfurafine hydrochloride is a kappa-opioid receptor agonist Learn More
  25. Nalmefene hydrochloride

    Catalog No. A13843
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    dopamine receptor agonist
    Nalmefene hydrochloride is an opioid receptor antagonist. Learn More
  26. U-69593

    Catalog No. A14187
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    κ1-opioid receptor agonist
    U-69593 is a potent, selective κ1-opioid receptor agonist (EC50 = 80-109 nM). Active in vivo. Antinociceptive. Learn More
  27. TRV130 (Oliceridine)

    Catalog No. A14337
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    μ-opioid receptor agonist
    TRV130 is an opioid drug that is under evaluation in human clinical trials for the treatment of acute severe pain. TRV130 elicits robust G protein signaling, with potency and efficacy similar to morphine, but with far less ??-arrestin 2 recruitment and receptor internalization, it displays less adverse effects than morphine. Learn More
  28. ADL5747

    Catalog No. A13479
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    δ opioid receptor agonist
    ADL5747 is a selective, nonpeptidic δ opioid receptor agonist. Learn More
  29. Alvimopan dihydrate

    Catalog No. A14991
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    µ-opioid receptor agonist
    Alvimopan dihydrate(LY 246736, ADL 8-2698) is a peripherally acting mu-opioid receptor (PAM-OR, IC50= 1.7 nM) antagonist for accelerating gastrointestinal recovery after surgery. Learn More
  30. ADL5859 HCl

    Catalog No. A11072
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    Opioid Receptor agonist
    ADL5859 HCl is a highly potent and selective δ opioid receptor agonist with Ki value to be 0.84 nM and ED50 value to be 20 nM. Learn More

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