Opioid Receptors

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  1. TRV130 HCl (Oliceridine)

    Catalog No. A15444
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    µ- opioid receptor agonist
    TRV 130 HCl is a novel μ-opioid receptor (MOR) G protein-biased ligand; elicits robust G protein signaling(pEC50=8.1), with potency and efficacy similar to morphine, but with far less beta-arrestin recruitment and receptor internalization. Learn More
  2. LY2795050

    Catalog No. A15149
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    k-opioid receptor antagonist
    LY2795050 is a novel selective κ-opioid Receptor (KOR) antagonist (IC50=0.72 nM) and has the potential as a PET tracer to image KOR in vivo. Learn More
  3. Methylnaltrexone Bromide

    Catalog No. A15159
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    μ-opioid antagonist
    Methylnaltrexone Bromide is a pheriphally-acting µ-opioid antagonist that acts on the gastrointestinal tract to decrease opioid-induced constipation. Learn More
  4. Eluxadoline

    Catalog No. A14085
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    opioid receptor agonist
    Eluxadoline is a novel, orally-active drug approved for the treatment of diarrhea and abdominal pain in individuals with diarrhea-predominant irritable bowel syndrome (IBS-D). Learn More
  5. Alvimopan dihydrate

    Catalog No. A14991
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    µ-opioid receptor agonist
    Alvimopan dihydrate(LY 246736, ADL 8-2698) is a peripherally acting mu-opioid receptor (PAM-OR, IC50= 1.7 nM) antagonist for accelerating gastrointestinal recovery after surgery. Learn More
  6. Alvimopan monohydrate

    Catalog No. A14992
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    µ-opioid receptor agonist
    Alvimopan monohydrate is a peripherally acting mu-opioid receptor (PAM-OR, IC50= 1.7 nM) antagonist for accelerating gastrointestinal recovery after surgery. Learn More
  7. ADL5859 HCl

    Catalog No. A11072
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    Opioid Receptor agonist
    ADL5859 HCl is a highly potent and selective δ opioid receptor agonist with Ki value to be 0.84 nM and ED50 value to be 20 nM. Learn More
  8. Naloxegol Oxalate

    Catalog No. A15972
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    Opioid antagonist
    Naloxegol is a peripherally-selective opioid antagonist for the treatment of opioid-induced constipation. Learn More
  9. Docusate Sodium

    Catalog No. A16155
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    Docusate Sodium is a laxative used to treat constipation, for constipation due to the use of opiates it maybe used with a stimulant laxative, can be taken by mouth or rectally. Learn More
  10. Cebranopadol (GRT-6005)

    Catalog No. A12670
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    Opioid Receptor Agonist
    Cebranopadol is a potent nociceptin/orphanin FQ peptide (NOP) and opioid receptor agonist Learn More
  11. ADL5747

    Catalog No. A13479
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    δ opioid receptor agonist
    ADL5747 is a selective, nonpeptidic δ opioid receptor agonist. Learn More
  12. TRV130 (Oliceridine)

    Catalog No. A14337
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    μ-opioid receptor agonist
    TRV130 is an opioid drug that is under evaluation in human clinical trials for the treatment of acute severe pain. TRV130 elicits robust G protein signaling, with potency and efficacy similar to morphine, but with far less ??-arrestin 2 recruitment and receptor internalization, it displays less adverse effects than morphine. Learn More
  13. JTC-801

    Catalog No. A11076
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    Opioid Receptor antagonist
    JTC-801 is a selective antagonist for the nociceptin receptor, also known as the ORL-1 receptor. Learn More
  14. MCOPPB 3HCl

    Catalog No. A10561
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    NOP receptor agonist
    MCOPPB is a compound which acts as a potent and selective agonist for the nociceptin receptor, with a pKi of 10.07. Learn More
  15. BRL 52537 HCl

    Catalog No. A11210
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    Opioid Receptors agonist
    BRL 52537 hydrochloride is a highly selective and potent κ-opioid agonist (Ki = 0.24 nM). 25 times more potent than morphine. Learn More
  16. Alvimopan (ADL 8-2698)

    Catalog No. A11292
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    Opioid antagonist
    Alvimopan behaves as a peripherally acting μ-opioid antagonist. Alvimopan competitively binds to mu-opioid receptor in the gastrointestinal tract. Learn More
  17. BAN ORL 24

    Catalog No. A11322
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    NOP antagonist
    BAN ORL 24 is a potent and selective NOP receptor antagonist. Learn More
  18. Trimebutine

    Catalog No. A11718
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    Trimebutine is a drug with antimuscarinic and weak mu opioid agonist effects. Learn More
  19. Nalfurafine hydrochloride

    Catalog No. A12579
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    opioid κ-selective agonist
    Nalfurafine hydrochloride is a kappa-opioid receptor agonist Learn More
  20. Nalmefene hydrochloride

    Catalog No. A13843
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    dopamine receptor agonist
    Nalmefene hydrochloride is an opioid receptor antagonist. Learn More
  21. U-69593

    Catalog No. A14187
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    κ1-opioid receptor agonist
    U-69593 is a potent, selective κ1-opioid receptor agonist (EC50 = 80-109 nM). Active in vivo. Antinociceptive. Learn More
  22. Bevenopran

    Catalog No. A17110
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    opioid receptor antagonis
    Bevenopran, also known as CB-5945, ADL-5945, MK-2402, OpRA III, is a peripherally selective μ- and δ-opioid receptor antagonist. Learn More

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