P-gp

Catalog No.Inhibitor Name P-gpOther
A10549Zosuquidar 3HCl
**
A11584Tariquidar
***
A12324Elacridar (GF120918)
BCRP

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. P-gp inhibitor 1

    Catalog No. A13384
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    P-gp inhibitor
    P-gp inhibitor 1 is a novel inhibitor reversing P-glycoprotein-mediated multidrug resistance. Learn More
  2. Norverapamil hydrochloride

    Catalog No. A12249
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    P-gp inhibitor
    Norverapamil hydrochloride ((±)-Norverapamil hydrochloride), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor. Learn More
  3. TTT-28

    Catalog No. A13033
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    ABCB1 (P-gp/MDR1) inhibitor
    TTT-28 is a synthesized thiazole-valine peptidomimetic, a novel selective inhibitor of ABCB1 (P-gp/MDR1) with high efficacy and low toxicity. Learn More
  4. Zosuquidar

    Catalog No. A15289
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    P-gp inhibitor
    Zosuquidar is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Learn More
  5. Elacridar hydrochloride

    Catalog No. A15077
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    P-gp inhibitor
    Elacridar hydrochloride is a P-glycoprotein inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules. Learn More
  6. Biricodar dicitrate (VX-710 dicitrate)

    Catalog No. A13533
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    P-gp modulator
    Biricodar dicitrate (VX-710 dicitrate) is a modulator of P-glycoprotein and MRP-1; shows effective chemosensitizing activity in multidrug resistant cells. Learn More
  7. Biricodar

    Catalog No. A21464
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    P-glycoprotein/MRP-1 modulator
    Biricodar (VX-710) is a modulator of P-glycoprotein and MRP-1; shows effective chemosensitizing activity in multidrug resistant cells. Learn More
  8. FD 12-9

    Catalog No. A18393
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    P-gp/BCRP dual inhibitor
    FD 12-9 is a flavonoid dimer, acts as a dual inhibitor of P-gp and BCRP, with EC50s of 285 nM and 0.9 nM, respectively. Anti-glioblastoma activity. Learn More
  9. KS-176

    Catalog No. A16195
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    BCRP inhibitor
    KS-176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter (IC50 values are 0.59 and 1.39 uM in Pheo A and Hoechst 33342 assays respectively). Learn More
  10. MC 70 HCl

    Catalog No. A16080
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    P-gp inhibitor
    MC-70 is a potent P-gp inhibitor (EC50 = 0.69 uM). Learn More
  11. LY335979 (Zosuquidar 3HCl)

    Catalog No. A10549
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    P-gp modulator
    LY335979 (Zosuquidar trihydrochloride) is a potent highly selective P-gp inhibitor. Learn More
  12. Laniquidar

    Catalog No. A13532
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    P-gp inhibitor
    Laniquidar is a third-generation P-gp inhibitor, which has been used in clinic trials for modulating multidrug resistance transporters. Learn More
  13. ONT-093

    Catalog No. A13531
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    P-gp inhibitor
    ONT-093 is an orally bioavailable P-glycoprotein pump inhibitor, for the potential reversal of multidrug resistance in patients undergoing cancer chemotherapy. Learn More
  14. XR9576

    Catalog No. A13961
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    P-glycoprotein inhibitor
    XR9576 is a P-glycoprotein inhibitor undergoing research as an adjuvant against multidrug resistance in cancer Learn More
  15. Cynarin

    Catalog No. A12004
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    Cynarin is a phenolic compound found in artichoke. It has antioxidant and choleretic properties. It is a potential immunosuppressive agent. Learn More
  16. Selamectin

    Catalog No. A12363
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    Selamectin is a topical parasiticide and antihelminthic used on dogs and cats to treat and prevent infections of heartworms, fleas, ear mites, sarcoptic mange, and certain types of ticks in dogs as well as prevent heartworms, fleas, ear mites, hookworms, and roundworms in cats. Learn More
  17. Tariquidar (XR9576)

    Catalog No. A11584
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    P-gp inhibitor
    Tariquidar (XR9576) is a P-glycoprotein drug efflux pump inhibitor. Learn More
  18. Elacridar (GF120918)

    Catalog No. A12324
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    P-gp & BCRP inhibitor
    Elacridaris a prototypical BCRP inhibitor which inhibits the Bcrp1-mediated transport. Learn More
  19. PSC-833 (Valspodar)

    Catalog No. A11080
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    MDR1/P-gp Inhibitor
    PSC-833 is a kind of P-glycoprotein (P-gp) modulator that inhibits P-gp-mediated multidrug-resistance (MDR). Learn More

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