Phospholipases

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  1. LY315920 (Varespladib)

    Catalog No. A10548
    HnsPLA inhibitor
    LY315920 (Varespladib) is an inhibitor of the IIa, V, and X isoforms of secretory phospholipase A2 (sPLA2). Learn More
  2. ML348

    Catalog No. A16338
    LYPLA1 inhibitor
    ML348 is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM), Exhibits 14-fold selectivity for LYPLA1 over LYPLA2, Also selective over a panel of ~30 other serine hydrolases. Learn More
  3. D609

    Catalog No. A11388
    PC-PLC inhibitor
    D609 is a selective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor (Ki = 6.4 μM); antiviral and antitumor agent. Learn More
  4. U 73122

    Catalog No. A14339
    Phospholipase C inhibitor
    U 73122 is a phospholipase C inhibitor. It inhibits agonist-induced platelet aggregation with IC50 values of 1-5 uM. Learn More
  5. Darapladib

    Catalog No. A14274
    Lp-PLA2 Inhibitor
    Darapladib is a reversible lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor . Learn More
  6. FIPI

    Catalog No. A13895
    PLD inhibitor
    Isoforms of phospholipase D (PLD) cleave the head group from phospholipids, releasing the second messenger phosphatidic acid (PA), which can produce changes in Ras activation, cell spreading, stress fiber formation, chemotaxis, and membrane vesicle trafficking. FIPI is a derivative of halopemide which potently inhibits both PLD1 (IC50 = 25 nM) and PLD2 (IC50 = 20 nM). Learn More
  7. Isotetrandrine

    Catalog No. A13411
    Isotetrandrine is a biscoclaurine alkaloid inhibitor of G protein activation of PLA2 but not PLC or PLD. Learn More
  8. Chlorpromazine is a dopamine antagonist of the typical antipsychotic class of medications possessing additional antiadrenergic, antiserotonergic, anticholinergic and antihistaminergic properties used to treat schizophrenia. Learn More
  9. Tanshinone I

    Catalog No. A10889
    Phospholipase inhibitor
    Tanshinones are the major bioactive compounds of Salvia miltiorrhiza Bunge (Danshen) roots, which are used in many therapeutic remedies in Chinese traditional medicine. Learn More
  10. MAO-B inhibitor
    Quercetin inhibits many enzyme systems including tyrosine protein kinase, phospholipase A2, phosphodiesterases, mitochondrial ATPase, PI 3-kinase and protein kinase C. Learn More
  11. Quercetin (Sophoretin)

    Catalog No. A10766
    MAO-B inhibitor
    Quercetin inhibits many enzyme systems including tyrosine protein kinase, phospholipase A2, phosphodiesterases, mitochondrial ATPase, PI 3-kinase and protein kinase C. Learn More
  12. Polydatin (Piceid)

    Catalog No. A10741
    PLA inhibitor
    Polydatin protects cerebral cells from ischemic damages via improvement of microcirculation and inhibition of platelet aggregation. In addition, polydatin inhibits ICAM-1 expression in endothelial cells stimulated by lipopolysaccharide; it also attenuates adhesion between white blood cells and endothelial cells. Learn More
  13. Clofazimine

    Catalog No. A16462
    Clofazimine is a rhimophenazine dye, originally developed for the treatment of tuberculosis, it has both antimicrobial and antiinflammatory activity, postulated mechanisms of action include intercalation of clofazimine with bacterial DNA and increasing levels of cellular phospholipase A2. Learn More

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