Phospholipases

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  1. LY315920 (Varespladib)

    Catalog No. A10548
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    HnsPLA inhibitor
    LY315920 (Varespladib) is an inhibitor of the IIa, V, and X isoforms of secretory phospholipase A2 (sPLA2). Learn More
  2. Polydatin (Piceid)

    Catalog No. A10741
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    PLA inhibitor
    Polydatin protects cerebral cells from ischemic damages via improvement of microcirculation and inhibition of platelet aggregation. In addition, polydatin inhibits ICAM-1 expression in endothelial cells stimulated by lipopolysaccharide; it also attenuates adhesion between white blood cells and endothelial cells. Learn More
  3. Quercetin (Sophoretin)

    Catalog No. A10766
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    MAO-B inhibitor
    Quercetin inhibits many enzyme systems including tyrosine protein kinase, phospholipase A2, phosphodiesterases, mitochondrial ATPase, PI 3-kinase and protein kinase C. Learn More
  4. Quercetin dihydrate (Sophoretin)

    Catalog No. A10765
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    MAO-B inhibitor
    Quercetin inhibits many enzyme systems including tyrosine protein kinase, phospholipase A2, phosphodiesterases, mitochondrial ATPase, PI 3-kinase and protein kinase C. Learn More
  5. Tanshinone I

    Catalog No. A10889
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    Phospholipase inhibitor
    Tanshinones are the major bioactive compounds of Salvia miltiorrhiza Bunge (Danshen) roots, which are used in many therapeutic remedies in Chinese traditional medicine. Learn More
  6. Chlorpromazine hydrochloride

    Catalog No. A10206
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    Chlorpromazine is a dopamine antagonist of the typical antipsychotic class of medications possessing additional antiadrenergic, antiserotonergic, anticholinergic and antihistaminergic properties used to treat schizophrenia. Learn More
  7. Isotetrandrine

    Catalog No. A13411
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    Isotetrandrine is a biscoclaurine alkaloid inhibitor of G protein activation of PLA2 but not PLC or PLD. Learn More
  8. FIPI

    Catalog No. A13895
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    PLD inhibitor
    Isoforms of phospholipase D (PLD) cleave the head group from phospholipids, releasing the second messenger phosphatidic acid (PA), which can produce changes in Ras activation, cell spreading, stress fiber formation, chemotaxis, and membrane vesicle trafficking. FIPI is a derivative of halopemide which potently inhibits both PLD1 (IC50 = 25 nM) and PLD2 (IC50 = 20 nM). Learn More
  9. Darapladib

    Catalog No. A14274
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    Lp-PLA2 Inhibitor
    Darapladib is a reversible lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor . Learn More
  10. U 73122

    Catalog No. A14339
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    Phospholipase C inhibitor
    U 73122 is a phospholipase C inhibitor. It inhibits agonist-induced platelet aggregation with IC50 values of 1-5 uM. Learn More
  11. D609

    Catalog No. A11388
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    PC-PLC inhibitor
    D609 is a selective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor (Ki = 6.4 μM); antiviral and antitumor agent. Learn More
  12. ML348

    Catalog No. A16338
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    LYPLA1 inhibitor
    ML348 is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM), Exhibits 14-fold selectivity for LYPLA1 over LYPLA2, Also selective over a panel of ~30 other serine hydrolases. Learn More
  13. Clofazimine

    Catalog No. A16462
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    Clofazimine is a rhimophenazine dye, originally developed for the treatment of tuberculosis, it has both antimicrobial and antiinflammatory activity, postulated mechanisms of action include intercalation of clofazimine with bacterial DNA and increasing levels of cellular phospholipase A2. Learn More

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