Smoothened

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  1. Purmorphamine

    Catalog No. A11480
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    Hedgehog signaling activator
    Purmorphamine is a 2,6,9-trisubstituted purine that promotes the differentiation of both human and mouse mesenchymal progenitor cells into osteoblasts. Learn More
  2. LDE225 Diphosphate

    Catalog No. A12774
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    Smoothened Inhibitor
    LDE225 is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. Learn More
  3. PF-5274857

    Catalog No. A12775
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    Smoothened Inhibitor
    PF-5274857 is a novel Smo antagonist that specifically binds to Smo with a K(i) of 4.6 ± 1.1 nmol/L and completely blocks the transcriptional activity of the downstream gene Gli1 with an IC(50) of 2.7 ± 1.4 nmol/L in cells. Learn More
  4. BMS-833923 (XL-139)

    Catalog No. A13204
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    Smoothened inhibitor
    BMS-833923 (or XL-139) is an orally bioavailable small-molecule SMO (Smoothened) inhibitor with potential antineoplastic activity. Learn More
  5. PF-04449913

    Catalog No. A13881
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    Smoothened inhibitor
    PF-04449913 is a potent and orally bioavailable inhibitor of smoothened. Learn More
  6. SAG

    Catalog No. A13627
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    SMO agonist
    SAG is a chlorobenzothiophene-containing compound which acts as a SMO agonist (EC50 = 3 nM) but inhibits hedgehog signaling at high concentrations (>1 uM). Learn More
  7. Jervine

    Catalog No. A16221
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    SMO inhibitor
    Jervine is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog(Shh) signaling; Jervine is an inhibitor of Smo. Learn More

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