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Purmorphamine
Catalog No. A11480 Hedgehog signaling activatorPurmorphamine is a 2,6,9-trisubstituted purine that promotes the differentiation of both human and mouse mesenchymal progenitor cells into osteoblasts. Learn More -
LDE225 Diphosphate
Catalog No. A12774 Smoothened InhibitorLDE225 is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. Learn More -
PF-5274857
Catalog No. A12775 Smoothened InhibitorPF-5274857 is a novel Smo antagonist that specifically binds to Smo with a K(i) of 4.6 ± 1.1 nmol/L and completely blocks the transcriptional activity of the downstream gene Gli1 with an IC(50) of 2.7 ± 1.4 nmol/L in cells. Learn More -
BMS-833923 (XL-139)
Catalog No. A13204 Smoothened inhibitorBMS-833923 (or XL-139) is an orally bioavailable small-molecule SMO (Smoothened) inhibitor with potential antineoplastic activity. Learn More -
Glasdegib (PF-04449913)
Catalog No. A13881 Smoothened inhibitorPF-04449913 is a potent and orally bioavailable inhibitor of smoothened. Learn More -
SAG
Catalog No. A13627 SMO agonistSAG is a chlorobenzothiophene-containing compound which acts as a SMO agonist (EC50 = 3 nM) but inhibits hedgehog signaling at high concentrations (>1 uM). Learn More -
Jervine
Catalog No. A16221 SMO inhibitorJervine is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog(Shh) signaling; Jervine is an inhibitor of Smo. Learn More
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