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Catalog No.
Product Name
Application
Product Information
Product Citation
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FXR agonist
GW4064 is a selective, non-steroidal farnesoid X receptor (FXR) agonist (EC50 = 15 nM).- Dong-Hyun Kim, .et al. , Cell Death Dis, 2021, Apr; 12(4): 320 PMID: 33767132
- Takae K, .et al. , J Reprod Dev, 2018, Nov 16 PMID: 30449821
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FXR agonist
WAY-362450 is a highly potent, selective, and orally bioavailable farnesoid X receptor (FXR) agonist (EC50: 4 nM, eff=149%).
- Dong-Hyun Kim, .et al. , Cell Death Dis, 2021, Apr; 12(4): 320 PMID: 33767132
- Dong-Hyun Kim, .et al. , FASEB J, 2019, Jul 12:fj201900325R PMID: 31298930
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FXR agonist
Lithocholic acid is a bile acid that acts as a detergent to solubilize fats for absorption. -
LXR/FXR agonist
T0901317 is a potent and selective agonist for LXR and FXR, with EC50s of 50 nM and 5 μM, respectively- A O Hamouda, .et al. , Eur Rev Med Pharmacol Sci, 2022, Dec;26(23):8644-8659 PMID: 36524484
- Tian Yongsong, .et al. , J Labelled Comp Radiopharm, 2022, Feb;65(2):36-44 PMID: 34957593
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FXR agonist
Obeticholic Acid is a potent and selective farnesoid X receptor (FXR) agonist with EC50 of 99 nM- Tomasz Kostrzewski, .et al. , Hepatol Commun, 2019, 13 November
- Sevelamer hydrochloride is a phosphate binding drug used to treat hyperphosphatemia in patients with chronic kidney disease; consists of polyallylamine that is crosslinked with epichlorohydrin.
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FXR anonist
Tropifexor, also known as LJN452, is a farnesoid X receptor agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH). - Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt.
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FXR agonist
Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity relative to natural compounds.
