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Potassium Channels



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Catalog No. Product Name Application Product Information
A11239 SALE

TAK-438 (vonoprazan)

potassium-competitive acid Blocker
TAK-438 is a novel potassium-competitive acid blocker.
A10783 SALE

Repaglinide

Potassium Channel inhibitor
Repaglinide is a potent short-acting insulin secretagogue that acts by closing ATP-sensitive potassium (KATP) channels in the plasma membrane of the pancreatic beta cell.
A13944

GW 542573X

KCa2.1 channels activator
GW 542573X is an activator of small-conductance Ca2+-activated K+ channels (KCa2).
A14971

20-HETE

-
20-HETE is a potent vasoconstrictor produced in vascular smooth muscle (VSM) cells.
A15222

Retigabine dihydrochloride

KCNQ channel opener
Retigabine dihydrochloride is a Kv7.2-7.5 (KCNQ2-5) neuronal potassium channel opener witrh anticonvulsant activity.
A15275 SALE

Vernakalant HCl

Ion channel blocker
Vernakalant Hcl is an investigational mixed ion channel blocker that can terminate acute atrial fibrillation (AF) in humans at 2 to 5 mg/kg and may be more atrial-selective than available agents; in treatment of antiarrhythmic.
A15493

KB130015

hERG1 potassium channel activator
KB130015 is a novel activator of hERG1 potassium channels, blocking native and recombinant hERG1 channels at high voltages, but activating them at low voltages.
A15503

ICA-110381

KV7.2/7.3 activator
ICA-110381 is a KV7.2/7.3 activator with EC50 of 0.38 uM.
A15929

NS-1643

hERG channel activator
NS-1643 is a Human ether-a-go-go related gene (hERG) KV11.1 channel activator (EC50 = 10.5 uM).
A15975 SALE

NS1619

Potassium channel activator
NS1619 is a Bkca opener or large-conductance Ca2+-activated potassium (BKCa, KCa1.1) channel activator.
A15961

Doxapram

-
Doxapram inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively. Doxapram is a respiratory stimulant. Administered intravenously, doxapram stimulates an increase in tidal volume, and respiratory rate.
A16182

K+ Channel inhibitor

K+ Channel inhibitor
K+ Channel inhibitor, building block for synthesis of dihydropyrazolopyrimidine inhibitors of Kv1.5 (IKur).
A10641

Nicorandil

Kir6 (KATP) channel opener
A10433 SALE

Glyburide

K+ channel and CFTR Cl- channel blocker
A11712 SALE

Orphenadrine citrate

-
Orphenadrine is known to have the following pharmacology: mACh receptor antagonist (anticholinergic); H1 receptor antagonist (antihistamine); NMDA receptor antagonist; NET blocker (norepinephrine reuptake inhibitor); Nav1.7, Nav1.8, and Nav1.9 sodium channel blocker; HERG potassium channel blocker.
A11934

NS 309

KCa3.1 channel activator
NS 309 is a positive modulator of small- and intermediate- conductance Ca2+-activated K+ channels (KCa2 and KCa3.1 channels).
A10430

Glimepiride

Kir6.2/SUR inhibitor
Glimepiride is a potent Kir6.2/SUR inhibitor with IC50 of 3.0 nM, 5.4 nM, and 7.3 nM for SUR1, SUR2A and SUR2B, used in the treatment of type 2 diabetes mellitus.
A11922 SALE

Retigabine (Ezogabine)

-
Retigabine is an anticonvulsant used as a treatment for partial epilepsies.
A10455 SALE

Hydralazine hydrochloride

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Hydralazine hydrochloride is a hydrochloride salt of hydralazine (Apresoline) that is a direct-acting smooth muscle relaxant with an IC50 of 1.9 mM.
A10593 SALE

Minoxidil (U-10858)

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Minoxidil (U-10858) is a selective ATP dependent K+ (Kir6) channel activator.
A10629

Nateglinide (Starlix)

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Nateglinide(Starlix) is an insulin secretagog agent that lowers blood glucose levels by stimulating insulin secretion from the pancreas.
A11884

Mitiglinide calcium

KATP channel antagonist
Mitiglinide is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells.
A11521 SALE

PAP-1 (5-(4-Phenoxybutoxy)psoralen)

Kv1.3 blocker
PAP-1 is a selective inhibitor of Kv1.3, voltage-gated potassium channel. PAP-1 (EC50=2 nM) potently inhibits human T effector memory cell proliferation and delayed hypersensitivity.
A12783 SALE

TRAM-34

Potassium Channel Blocker
TRAM-34 is a highly selective blocker of intermediate conductance Ca2+-activated K+ channels (KCa3.1) (Kd = 20 nM). Exhibits 200-1500-fold selectivity over KV, BKCa, KCa2, Na+, CRAC and Cl- channels. Suppresses the reactivation of lymphocytes by mitogenic stimuli.
A12857

E-4031 dihydrochloride

K+ channel blocker‎
E-4031 dihydrochloride is a selective blocker of KV11.1 (hERG) channels; inhibits the rapid delayed-rectifier K+ current (IKr).
A15341

Cesium chloride

Potassium channel blocker
Cesium chloride is a potassium channel blocker; inhibits the pacemaker current (If) and the hyperpolarization-activated cationic current (Ih). Prevents activation of caspase-3 and neuronal apoptosis in serum- and potassium-deprived cerebellar granule neurons by inactivating GSK-3β.

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