Catalog No.

Product Name

Application

Product Information

Product Citation

A11126

BINA

mGluR2 modulator

BINA is a selective positive allosteric modulator of mGlu2 (EC50 = 33.2 nM in CHO cells expressing human mGlu2).

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A11382

Dipraglurant

mGluR5 antagonists

Dipraglurant (ADX 48621) is a mGluR5 antagonists with IC50 of 0.021 μM.

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A11968

CTEP

CTEP is a highly potent, selective and orally bioavailable allosteric antagonist of mGlu5 receptor with an IC50 of 2.2 nM.

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A12139

VU 0364770

mGlu4 receptors modulator

VU 0364770 is a positive allosteric modulator at mGlu4 receptors with EC50 value of 290 nM in mGlu4-expressing HEK 293 cells.

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A12705

PHCCC

mGluR antagonist

PHCCC is a group I metabotropic glutamate receptor antagonist (IC50 ~ 3 μM).

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A13123

LY 379268

mGlu2 receptor agonist

LY 379268 is a highly selective group II mGlu receptor agonist (EC50 values are 2.69 and 4.48 nM for hmGlu2 and hmGlu3 respectively) that displays > 80-fold selectivity over group I and group III receptors.

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A13236

MPEP HCl

mGlu5 receptor antagonist

MPEP is a potent, highly selective non-competitive antagonist at the mGlu5a receptor subtype (IC50 = 36 nM) while having no agonist or antagonist activities at the mGlu1b receptor at concentrations up to 30 uM.

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A13854

A-841720

mGluR-1 antagonist

A 841720 is a potent, non-competitive mGluR-1 antagonist that displays 34-fold selectivity over mGluR-5 (IC50 values are 10 and 342 nM respectively).

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A14006

Ibotenic Acid

NMDA& mGlu receptor agonist

Ibotenic acid is a neuroexcitatory amino acid originally isolated from Amanita species that functions as a NMDA and metabotropic glutamate receptor agonist.

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A14330

JNJ 42153605

mGluR-2 modulator

JNJ-42153605 is a positive allosteric modulator of the metabotropic glutamate 2 receptor.

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A15811

CBiPES HCl

mGlu2 receptor modulator

CBiPES hydrochloride is a selective positive allosteric modulator of the mGluR-2 with IC50 value of 98.2 nM

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A15832

VU0364289

mGluR5 Modulator

VU0364289 is a novel N-aryl piperazine mGlu5 positive allosteric modulator.

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A17023

VU6005649

CNS penetrant mGlu7/8 receptor agonist

VU6005649 is a CNS penetrant mGlu7/8 receptor agonist with EC50s of 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively.

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A20495

MSOP

group III mGluR antagonist

MSOP is a selective group III metabotropic glutamate receptor antagonist with apparent KD of 51 μM for the L-AP4-sensitive presynaptic mGluR.

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A20558

DFMTI

mGluR1 receptors Modulator

DFMTI is an allosteric negative modulator of mGluR1 receptors.

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A20674

FPTQ

mGluR1 antagonist

FPTQ is mGluR1 antagonist with IC50 of 6 nM and 1.4 nM for human and mouse mGluR1 respectively.

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A20732

JNJ-46778212

mGlu5 modulator

JNJ-46778212 (VU 0409551) is an mGlu5 positive allosteric modulator with an EC50 of 260 nM.

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A20922

ADX88178

mGluR4 PAM

ADX88178 is a potent metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) with an EC50 of 4 nM for human mGluR4.

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A21100

LY2812223

mGlu2 receptor agonist

LY2812223 is a highly potent, functionally selective mGlu2 receptor agonist with mGlu2 binding affinity for mGlu2 and mGlu3 (Ki=144 nM and 156 nM, respectively).

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A21887

(R)-ADX-47273

mGluR5 positive allosteric modulator

(R)-ADX-47273 is a potent mGluR5 positive allosteric modulator, with an EC50 of 168 nM for potentiation .

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A22631

NPS2390

group I mGlu antagonist

NPS2390 is a group I mGlu antagonist. It displays noncompetitive antagonist activity at both mGlu1 and mGlu5 receptors. NPS2390 is thought to act on a site separate from the glutamate binding pocket.

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Metabotropic glutamate receptors (mGluR)