Metabolism

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  1. p32-kinase activator

    D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator.
  2. antioxidant

    2-Phospho-L-ascorbic acid trisodium acts as an antioxidant and a stimulator of hepatocyte growth factor (HGF) production.
  3. Pimecrolimus is a natural ascomycin macrolactam that binds to macrophilin-12 (FKBP-12) and inhibits calcineurin as well as prolyl isomerase (rotamase).
  4. protein tyrosine phosphatases inhibitor

    Sodium orthovanadate is the chemical compound Na3VO4. It is an inhibitor of protein tyrosine phosphatases, alkaline phosphatases and a number of ATPases, most likely acting as a phosphate analogue.
  5. Phosphatase inhibitor

    NSC 95397 is a selective and effective dual-specificity, quinone-based phosphatase inhibitor.
  6. PP2A inhibitor

    Calyculin A is a potent and cell-permeable protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor with IC50s of 2 nM and 0.5-1 nM.
  7. PPP1R15A inhibitor

    Sephin1 is a selective inhibitor of stress-induced PPP1R15A and targets disease associated with accumulation of misfolded protein.
  8. SHIP1 Inhibitor

    3AC is a cell-permeable, selective inhibitor of SHIP1 polyphosphatase activity toward PIP3 (IC50 = 10 μM), but has no effect on SHIP2 or PTEN activity on PIP3.
  9. phosphatase inhibitor

    (-)-p-Bromotetramisole Oxalate is a potent and non-specific alkaline phosphatase inhibitor.
  10. CCT007093 is a potent PPM1D (WIP1) inhibitor with IC50 of 8.4 μM.
  11. eIF2α phosphatase inhibitor

    Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor.
  12. Ser/Thr protein phosphatase activator

    Ceramide is a ceramide shown to be a potent modulator of proliferation and differentiation, used as a tool for studying the complex signaling associated with the ceramides.
  13. Wip1 phosphatase inhibitor

    GSK 2830371 is a highly selective Wip1 phosphatase inhibitor with IC50 of 6 nM.
  14. Eukaryotic ribosome biogenesis inhibitor

    Rbin-1 is a potent, reversible, and specific chemical inhibitor of eukaryotic ribosome biogenesis. Rbin-1 inhibits the ATPase with GI50 of 136 nM. Rbin-1 is a potent and selective chemical inhibitor of Midasin (Mdn1).
  15. DUSP26 inhibitor

    F1063-0967 is a novel inhibitor of dual-specificity phosphatase 26 (DUSP26), inducing apoptosis in IMR-32 cell line.
  16. TNAP inhibitor

    SBI-425 is a potent, selective and oral bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor.
  17. Phosphatase inhibitor

    Enocyanin is an anthocyanin extracted from grapes. Enocyanin shows inhibitory effect on the leucine aminopeptidase, acid phosphatase, γ-glutamyl transpeptidase and esterase activity.
  18. PPP1R15B inhibitor

    Raphin1 is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B).
  19. CDC25 phosphatase family inhibitor

    BN82002 is a potent, selective and irreversible inhibitor of CDC25 phosphatase family.
  20. DCP-LA (FR236924), a linoleic acid derivative, selectively and directly activates PKCε.
  21. SHIP-2 inhibitor

    AS1949490 is a potent and selective SHIP-2 (SH2 domain-containing inositol 5?? phosphatase 2) inhibitor, with an IC50 of 620 nM. AS1949490 activated glucose metabolism via up-regulation of GLUT1 gene in L6 myotubes.
  22. PPP1R15B inhibitor

    Raphin1 acetate is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B).
  23. PLD1/PLD2 dual inhibitor

    ML299 (VU0463568) is a dual inhibitor of PLD1 and PLD2 with IC50 of 6 nM and 20 nM, respectively.
  24. D-3, a phosphorpeptide, is an efficient, simple, and specific iPSC-eliminating agent.

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