DNA Methyltransferases

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  1. O6BTG-octylglucoside

    Catalog No. A11432
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    MGMT inhibitor
    O6BTG-octylglucoside is a potent O6-methylguanine-DNAmethyl-transferase (MGMT) inhibitor, with IC50s of 32 nM in vitro (cell extracts) and 10 nM in HeLa S3 cells. Learn More
  2. 6-Methyl-5-azacytidine

    Catalog No. A13391
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    DNMT inhibitor
    6-Methyl-5-azacytidine is a potent DNMT inhibitor. Learn More
  3. CM-579

    Catalog No. A18692
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    G9a/DNMT inhibitor
    CM-579 is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells. Learn More
  4. CM-272

    Catalog No. A17173
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    G9a/DNMT inhibitor
    CM-272 is a reversible dual small molecule inhibitor against G9a and DNMTs in hematological malignancies. CAS: 1846570-31-7 (free base) 1846570-32-8 (TFA) Learn More
  5. Lomeguatrib

    Catalog No. A12785
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    MGMT inhibitor
    Lomeguatrib is a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase. Learn More
  6. Nanaomycin A

    Catalog No. A13477
    DNMT3B inhibitor
    Nanaomycin A is a selective inhibitor of DNA methyltransferase 3B (DNMT3B) with IC50 value of 500 nM. Learn More
  7. O6-Benzylguanine

    Catalog No. A13706
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    MGMT inhibitor
    O6-Benzylguanine is an effective substrate and efficient inactivator of DNA alkyltransferase. O6-Benzylguanine is an inhibitor of MGMT. Learn More
  8. RG108

    Catalog No. A13054
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    DNA methyltransferase inhibitor
    RG108 is a non-nucleoside inhibitor of DNA methyltransferase with IC50 of 115 nM. Learn More
  9. Procainamide HCl

    Catalog No. A14240
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    Sodium channel blocker/DNMT inhibitor
    Procainamide HCl is a sodium channel blocker, and also a DNA methyltransferase inhibitor. Learn More
  10. SGI 1027

    Catalog No. A14120
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    DNMT inhibitor
    SGI 1027 is a DNMT inhibitor with IC50 of 6, 8, 7.5 uM for DNMT1, DNMT3A, and DNMT3B, respectively. Learn More
  11. SGI-110 (Guadecitabine)

    Catalog No. A12744
    DNMT inhibitor
    SGI-110 is a second generation DNA-hypomethyating agent. Learn More
  12. Azacitidine(Vidaza)

    Catalog No. A10105
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    DNMT inhibitor
    Azacitidine is a chemical analogue of the cytosine nucleoside used in DNA and RNA that is mainly used in the treatment of myelodysplastic syndrome (MDS). Learn More
  13. Decitabine

    Catalog No. A10292
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    DNA Methyltransferase Inhibitors
    Decitabine is a hypomethylating agent.It hypomethylates DNA by inhibiting DNA methyltransferase. Learn More
  14. (-)-Epigallocatechin gallate

    Catalog No. A10005
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    Antioxidant, antiangiogenic, antitumor agent
    (-)-Epigallocatechin gallate is a potent anti-oxidant polyphenol flavonoid isolated from green tea. Learn More

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