Serine Protease

Catalog No.Inhibitor Name Serine ProteaseOther
A14263Aprotinin
***
Thrombin,Trypsin,kallikrein
A12779Alvelestat (AZD9668)
****
A10617Nafamostat Mesylate
A11901PMSF
cysteine protease
A14145Leupeptin Hemisulfate
Cysteine protease
A14270AEBSF HCl

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Upamostat

    Catalog No. A21035
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    serine protease inhibitor
    Upamostat is a serine protease inhibitor. Upamostat is the orally available prodrug of the WX-UK1, which is a urokinase plasminogen activator (uPA) inhibitor. Learn More
  2. Nafamostat

    Catalog No. A20827
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    serine protease inhibitor
    Nafamostat is an anticoagulant. Broad spectrum serine protease inhibitor. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma. Learn More
  3. Nafamostat hydrochloride

    Catalog No. A20828
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    serine protease inhibitor
    Nafamostat hydrochloride is an anticoagulant. Broad spectrum serine protease inhibitor. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma. Learn More
  4. SPHINX31

    Catalog No. A18640
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    Serine/arginin kinase 1 inhibitor
    SPHINX31 is a potent inhibitor of serine/arginine-rich protein kinase 1 (SRPK1; IC50 = 5.9 nM). Learn More
  5. AA26-9

    Catalog No. A17158
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    serine hydrolase inhibitor
    AA26-9 is a potent and broad-spectrum serine hydrolase inhibitor. Learn More
  6. Fumonisin B1

    Catalog No. A15379
    serine/threonine phosphatase inhibitor
    Fumonisin B1 is a fungal metabolite produced by Fusarium moniliforme, that has been shown to inhibit protein serine/threonine phosphatases (PP1, PP2A, PP2B, PP2C, and PP5/T/K/H), and is most effective with PP5. Learn More
  7. SSR 69071

    Catalog No. A15315
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    HLE inhibitor
    SSR 69071 is a high affinity, potent inhibitor of Neutrophil Elastase (human leukocyte elastase, HLE) (IC50 = 3.9 nM). Learn More
  8. PMSF

    Catalog No. A11901
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    Serine/cysteine protease inhibitor
    PMSF is an irreversible serine/cysteine protease inhibitor. Learn More
  9. Sivelestat sodium hydrate (ONO-5046 sodium hydrate)

    Catalog No. A16137
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    Neutrophil elastase inhibitor
    Sivelestat sodium is a competitive inhibitor of human neutrophil elastase, also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse. Learn More
  10. AAF-CMK

    Catalog No. A13605
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    Serine protease inhibitor
    AAF-CMK is a serine protease inhibitor which irreversibly inhibits TPPII (tripeptidyl peptidase II), a giant protease which may substitute for some proteasome functions1, and reversibly inhibits Cln2 (TPPI). Learn More
  11. Sivelestat

    Catalog No. A14184
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    Neutrophil elastase inhibitor
    Sivelestat is a cell-permeable sulfanilide compound that acts as a potent, substrate-competitive, and highly specific inhibitor of neutrophil elastase (IC50 = 19-49 nM in rat, rabbit, hamster, human, and mouse leukocyte elastase). Learn More
  12. BCX 1470

    Catalog No. A11331
    Serine protease inhibitor
    BCX 1470 is serine protease inhibitor. BCX 1470 blocks the esterolytic and hemolytic activities of the complement enzymes Cls and factor D in vitro. Learn More
  13. BCX 1470 methanesulfonate

    Catalog No. A11325
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    Serine protease inhibitor
    BCX 1470 is serine protease inhibitor. BCX 1470 blocks the esterolytic and hemolytic activities of the complement enzymes Cls and factor D in vitro. Learn More
  14. Camostat mesylate

    Catalog No. A11764
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    Camostat mesylate is an orally active protease inhibitor. Known to inhibit trypsin and various inflammatory proteases including plasmin, kallikrein and thrombin. Learn More
  15. Sivelestat sodium salt

    Catalog No. A14073
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    Neutrophil elastase inhibitor
    Sivelestat sodium salt is a selective leukocyte elastase inhibitor (IC50 = 44 nM) that displays no activity at a range of other proteases. It inhibits NF-kB activation and LTB4-induced neutrophil transmigration in vitro. Learn More
  16. Alvelestat

    Catalog No. A12779
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    neutrophil elastase inhibitor
    Avelestat, also known as AZD9668, is a novel, oral inhibitor of neutrophil elastase (NE). Learn More
  17. Leupeptin hemisulfate

    Catalog No. A14145
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    Cysteine Protease inhibitor
    Leupeptin hemisulfate is a reversible inhibitor of trypsin-like and cysteine proteases such as calpain. Learn More
  18. AEBSF HCl

    Catalog No. A14270
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    serine protease inhibitor
    AEBSF HCl is a broad spectrum, irreversible serine protease inhibitor. Learn More
  19. Aprotinin

    Catalog No. A14263
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    serine protease inhibitor
    Aprotinin is a small protein serine protease inhibitor, used to reduce perioperative blood loss and transfusion. Learn More
  20. Nafamostat mesylate

    Catalog No. A10617
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    serine protease inhibitor
    Nafamostat is an anticoagulant. Broad spectrum serine protease inhibitor. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma. Learn More

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