Kinesin Spindle Protein



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Catalog No. Product Name Application Product Information
A11050

Arry-520 (Filanesib)

KSP inhibitor
KSP inhibitor ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5) with potential antineoplastic activity.
A11170

AZ 3146

Mps1 inhibitor

AZ 3146 is a potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 35 nM). It interferes with chromosome alignment and overrides spindle assembly checkpoint and also Inhibits the recruitment of Mad1, Mad2 and centromere protein E (CENP-E) to kinetochores.

A15841

Dimethylenastron

Kinesin Eg5 inhibitor
Dimethylenastron is an inhibitor of mitotic motor kinesin Eg5 with IC50 value of 200 nM.
A10486

Ispinesib (SB-715992)

KSP Inhibitor
Ispinesib (SB-715992) is a potent inhibitor of kinesin spindle protein, a kinesin motor protein essential for the formation of a bipolar mitotic spindle and cell cycle progression through mitosis.
A15844

K 858

Kinesin Eg5 inhibitor
K 858 is a selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor with IC50 value of 1.3 uM.
A11976

Monastrol

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Monastrol is a potent, cell permeable non-tubulin-interacting mitosis inhibitor. Monastrol blocks mitosis (IC5N/A = 14 ?M) by binding to the mitotic kinesin Eg5, a motor protein required for spindle bipolarity.
A10828

SB 743921

KSP Inhibitor
SB 743921, a second generation KSP inhibitor, is a highly potent and active therapeutic in preclinical models of cancer.

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