TNF-α

Inhibitory Selectivity
Catalog No.Inhibitor Name TNF-αOther
A10743Pomalidomide
***
A11973Necrostatin-1
*
A12748QNZ
****
NF-κB
A10924Thalidomide
A10522Lenalidomide (CC-5013)
***

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



9 Item(s)

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Catalog No. Product Name Application Product Information
A11974 SALE

GW 4869

neutral sphingomyelinases inhibitor
W4869 is a cell permeable, selective inhibitor of N-SMase (neutral sphingomyelinase).
A10522 SALE

Lenalidomide (CC-5013)

Ubiquitin ligase inducer
Lenalidomide is a derivative of thalidomide. In vitro, lenalidomide has three main activities: direct anti-tumor effect, inhibition of the micro environment support for tumor cells, and immunomodulatory role. It induces tumor cell apoptosis directly and indirectly by inhibition of bone marrow stromal cell support, by anti-angiogenic and anti-osteoclastogenic effects, and by immunomodulatory activity.
A15183

Necrostatin 2

Necroptosis inhibitor
Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.
A15327

Necrostatin 2 racemate

Necroptosis inhibitor
Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.
A15328

Necrostatin 2 S enantiomer

Necroptosis inhibitor
Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.
A11973 SALE

Necrostatin-1

RIPK1 inhibitor
Necrostatin-1 is an ATP-competitive, allosteric inhibitor of receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM).
A10743 SALE

Pomalidomide (CC-4047)

TNF-alpha inhibitor
Pomalidomide is a derivative of thalidomide and acts as an immunomodulator.
A12748 SALE

QNZ (EVP4593)

NF-κB inhibitor
QNZ inhibits the activation of the transcription factor NF-κB and has been used to investigate NF-κB signaling.
A10924

Thalidomide

E3 ubiquitin ligase inhibitor
Thalidomide can directly inhibit angiogenesis induced by bFGF or VEGF in vivo.

9 Item(s)

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