AMPA receptor

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  1. PF-4778574

    Catalog No. A21157
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    AMPA receptor positive allosteric modulator
    PF-4778574 is a potent AMPA receptor positive allosteric modulator (PAM) that has been shown to enhance cognition in animal models. Learn More
  2. YM90K hydrochloride

    Catalog No. A15495
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    AMPA antagonist
    YM90K hydrochloride is a selective AMPA receptor antagonist that delays neuronal death in a global ischemia model and cerebral infarction in a focal ischemia model following postischemic administration. Learn More
  3. Talampanel

    Catalog No. A15515
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    AMPA/kainate receptor antagonist
    Talampanel is a non-competitive antagonist of AMPA-receptor. Learn More
  4. CP 465022 hydrochloride

    Catalog No. A13321
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    AMPA antagonist
    CP 465022 is a selective, non-competitive AMPA antagonist with IC50 of 25 nM in rat cortical neurons that displays potent anticonvulsant activity. Learn More
  5. Naspm trihydrochloride

    Catalog No. A21437
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    CP-AMPA receptors antagonist
    Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist. Learn More
  6. (S)-(-)-5-Fluorowillardiine

    Catalog No. A21337
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    AMPAR agonist
    (S)-(-)-5-Fluorowillardiine is a potent and specific AMPAR agonist. Learn More
  7. Fanapanel

    Catalog No. A21200
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    AMPA/kainate antagonist
    Fanapanel (ZK200775) is a highly selective AMPA/kainate antagonist with little activity against NMDA; have Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively. Learn More
  8. JNJ-61432059

    Catalog No. A20209
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    AMPAR negative modulator
    JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8, with a pIC50 of 9.7 for GluA1/γ-8. Learn More
  9. SYM2206

    Catalog No. A20843
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    AMPA receptor antagonist
    SYM 2206 is a novel, potent, non-competitive AMPA receptor antagonist. Learn More
  10. Tezampanel

    Catalog No. A15259
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    AMPA antagonist
    Tezampanel is an antagonist at the AMPA and kainate families of ionotropic glutamate receptors, with selectivity for the GluR5 subtype of the kainate receptor. Learn More
  11. Fanapanel hydrate

    Catalog No. A21668
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    AMPA/kainate antagonist
    Fanapanel hydrate (ZK200775 hydrate) is a highly selective AMPA/kainate antagonist with little activity against NMDA; have Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively. Learn More
  12. Naspm

    Catalog No. A21919
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    AMPA (CP-AMPA) receptors antagonist
    Naspm (1-Naphthyl acetyl spermine), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist. Learn More
  13. CMPDA

    Catalog No. A21909
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    AMPA receptors positive allosteric modulator
    CMPDA is a positive allosteric modulator of AMPA receptors with EC50s of 45.4 ?? 4.2 nM/63.4 ?? 5.6 nM for GluA2i/GluA2o receptor. Learn More
  14. PEPA

    Catalog No. A21904
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    AMPA receptors allosteric modulator
    PEPA is an allosteric modulator of AMPA receptors; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity. Learn More
  15. Philanthotoxin 74 dihydrochloride

    Catalog No. A21739
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    AMPAR antagonist
    Philanthotoxin 74 dihydrochloride (PhTx 74) is an AMPAR antagonist; inhibits GluR3 and GluR1 with IC50s of 263 and 296 nM, respectively. Learn More
  16. Mibampator

    Catalog No. A21717
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    AMPA receptors potentiator
    Mibampator (LY451395) is a potent and highly selective potentiator of the AMPA receptors. Learn More
  17. CX546

    Catalog No. A21923
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    positive AMPAR modulator
    CX546 is a selective positive AMPAR modulator; the prototypical ampakine agent. Learn More
  18. CFM-2

    Catalog No. A21930
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    non-competitive AMPAR antagonist
    CFM-2 is a selective non-competitive AMPAR antagonist. Learn More
  19. (S)-Willardiine

    Catalog No. A21957
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    AMPA/kainate receptors agonist
    (S)-Willardiine is a potent agonist of AMPA/kainate receptors with EC50 of 44.8 uM. Learn More
  20. Aniracetam

    Catalog No. A10078
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    AMPA Receptor Inhibitor
    Aniracetam is an ampakine and nootropic of the racetam chemical class purported to be considerably more potent than piracetam. Learn More
  21. GYKI53655 Hydrochloride

    Catalog No. A17032
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    AMPA antagonist
    GYKI53655 Hydrochloride is a non-competitive AMPA and kainate receptor antagonist. CAS: 143692-18-6 (Free Base); 143692-48-2 (HCl). Learn More
  22. Ampalex (CX-516)

    Catalog No. A12349
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    Ampalex is an ampakine and nootropic that acts as an AMPA receptor positive allosteric modulator Learn More
  23. GYKI-52466 dihydrochloride

    Catalog No. A10444
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    AMPA and Kainate antagonist
    GYKI-52466 dihydrochloride is selective non-competitive AMPA receptor antagonist (IC50 values are 10-20, ~ 450 and >> 50 μM for AMPA- , kainate- and NMDA-induced responses respectively). Learn More
  24. LY404187

    Catalog No. A12424
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    LY404187 is a selective, potent and centrally active positive allosteric modulator of AMPA receptors. Learn More
  25. LY450108

    Catalog No. A12425
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    LY450108 is an alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor potentiator. Learn More
  26. NBQX

    Catalog No. A13109
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    AMPA Receptor Antagonist
    NBQX is a potent, selective and competitive AMPA receptor antagonist. Learn More
  27. DNQX

    Catalog No. A13882
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    NMDA receptor antagonist
    DNQX is a non-N-methyl-D-aspartate (non-NMDA) receptor complex antagonist. Learn More
  28. IEM 1754 Dihydrobromide

    Catalog No. A14010
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    AMPA Receptor Blocker
    IEM 1754 Dihydrobromide is a voltage-dependent open-channel blocker of AMPA receptors. Learn More
  29. Farampator

    Catalog No. A13798
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    AMPA receptor modulator
    Farampator has been investigated for its effect on AMPA receptors and researched for potential use in the treatment of schizophrenia and Alzheimer's Disease. It was found to improve short-term memory, but impaired episodic memory. Learn More
  30. Cyclothiazide

    Catalog No. A13700
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    AMPA desensitization inhibitor
    Cyclothiazide is a benzothiadiazide that acts as a potentiator of AMPA receptors, positively modulating its response to glutamic acid (EC50 = 3.8 M). Learn More
  31. CNQX

    Catalog No. A16109
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    AMPA/kainate antagonist
    CNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 uM for AMPA and kainate receptors, respectively, versus IC50 = 25 uM for NMDA receptors). Learn More
  32. CNQX disodium salt

    Catalog No. A16110
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    AMPA/kainate antagonist
    CNQX disodium salt, water-soluble form of AMPA/kainate antagonist CNQX (GLXC-11053). Learn More
  33. Becampanel

    Catalog No. A21194
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    AMPA antagonist
    Becampanel (AMP397) is the first competitive AMPA antagonist and an antiepileptic agent. Learn More

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