Hydroxylases
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Nepicastat HCl
Catalog No. A11172 DBH inhibitorNepicastat hydrochloride is an inhibitor of dopamine beta-hydroxylase, an enzyme that catalyzes the conversion of dopamine to norepinephrine.
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Tetrahydropapaverine HCl
Catalog No. A10920 Hydroxylase inhibitorTetrahydropapaverine, one of the TIQs and an analogue of salsolinol and tetrahydropapaveroline, has been reported to have neurotoxic effects on dopamine neurons. Learn More -
LX 1606 Hippurate
Catalog No. A10542 Hydroxylase InhibitorLX 1606 hippurate is an orally bioavailable, small-molecule, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity. Learn More -
Nepicastat (free base) (SYN-117)
Catalog No. A10637 dopamine beta-hydroxylase inhibitorNepicastat is an inhibitor of dopamine beta-hydroxylase, an enzyme that catalyzes the conversion of dopamine to norepinephrine. Learn More -
LX 1606 (Telotristat)
Catalog No. A11785 Serotonin synthesis inhibitorLX 1606 is an orally bioavailable, small-molecule, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity. Learn More -
Isotretinoin
Catalog No. A10485 Isotretinoin was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more. Learn More -
Ro 61-8048
Catalog No. A12833 Hydroxylase InhibitorRo 61-8048 is a potent and competitive kynurenine 3-hydroxylase inhibitor (Ki = 4.8 nM, IC50 = 37 nM). Learn More -
Metyrapone
Catalog No. A13363 Cytochrome P450 inhibitorMetyrapone is an inhibitor of cytochrome P450-mediated ω/ω-1 hydroxylase activity and CYP11B1. Learn More -
DMOG
Catalog No. A13998 HIF-PH inhibitorDMOG is a cell permeable, competitive inhibitor of HIF-PH. It acts to stabilize HIF-1α expression at normal oxygen tensions in cultured cells, at concentrations between 0.1 and 1 mM. Learn More -
LP-533401
Catalog No. A14325 -
Collagen proline hydroxylase inhibitor
Catalog No. A11371 Collagen proline hydroxylase inhibitorCollagen proline hydroxylase inhibitor is a collagen proline hydroxylase inhibitor. Learn More -
LCI-699 (Osilodrostat)
Catalog No. A14013 11β-hydroxylase inhibitorOsilodrostat (LCI699) is a potent inhibitor of human 11β-hydroxylase and aldosterone synthase with IC50 values of 2.5 and 0.7 nM, respectively. Learn More -
Panaxtriol
Catalog No. A14602 -
4-Chloro-DL-phenylalanine
Catalog No. A16424 Tryptophan hydroxylase inhibitor4-Chloro-DL-phenylalanine is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Learn More