Hydroxylases

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  1. Nepicastat HCl

    Catalog No. A11172
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    DBH inhibitor

    Nepicastat hydrochloride is an inhibitor of dopamine beta-hydroxylase, an enzyme that catalyzes the conversion of dopamine to norepinephrine.

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  2. Tetrahydropapaverine HCl

    Catalog No. A10920
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    Hydroxylase inhibitor
    Tetrahydropapaverine, one of the TIQs and an analogue of salsolinol and tetrahydropapaveroline, has been reported to have neurotoxic effects on dopamine neurons. Learn More
  3. LX 1606 Hippurate

    Catalog No. A10542
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    Hydroxylase Inhibitor
    LX 1606 hippurate is an orally bioavailable, small-molecule, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity. Learn More
  4. Nepicastat (free base) (SYN-117)

    Catalog No. A10637
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    dopamine beta-hydroxylase inhibitor
    Nepicastat is an inhibitor of dopamine beta-hydroxylase, an enzyme that catalyzes the conversion of dopamine to norepinephrine. Learn More
  5. LX 1606 (Telotristat)

    Catalog No. A11785
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    Serotonin synthesis inhibitor
    LX 1606 is an orally bioavailable, small-molecule, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity. Learn More
  6. Isotretinoin

    Catalog No. A10485
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    Isotretinoin was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more. Learn More
  7. Ro 61-8048

    Catalog No. A12833
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    Hydroxylase Inhibitor
    Ro 61-8048 is a potent and competitive kynurenine 3-hydroxylase inhibitor (Ki = 4.8 nM, IC50 = 37 nM). Learn More
  8. Metyrapone

    Catalog No. A13363
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    Cytochrome P450 inhibitor
    Metyrapone is an inhibitor of cytochrome P450-mediated ω/ω-1 hydroxylase activity and CYP11B1. Learn More
  9. DMOG

    Catalog No. A13998
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    HIF-PH inhibitor
    DMOG is a cell permeable, competitive inhibitor of HIF-PH. It acts to stabilize HIF-1α expression at normal oxygen tensions in cultured cells, at concentrations between 0.1 and 1 mM. Learn More
  10. LP-533401

    Catalog No. A14325
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    Tph1 inhibitor
    LP-533401 is a small molecule inhibitor of Tph1. Learn More
  11. Collagen proline hydroxylase inhibitor

    Catalog No. A11371
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    Collagen proline hydroxylase inhibitor
    Collagen proline hydroxylase inhibitor is a collagen proline hydroxylase inhibitor. Learn More
  12. LCI-699 (Osilodrostat)

    Catalog No. A14013
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    11β-hydroxylase inhibitor
    Osilodrostat (LCI699) is a potent inhibitor of human 11β-hydroxylase and aldosterone synthase with IC50 values of 2.5 and 0.7 nM, respectively. Learn More
  13. Panaxtriol

    Catalog No. A14602
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    Tyrosine hydroxylase inducer
    Panaxtriol is a tyrosine hydroxylase inducer. Learn More
  14. 4-Chloro-DL-phenylalanine

    Catalog No. A16424
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    Tryptophan hydroxylase inhibitor
    4-Chloro-DL-phenylalanine is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Learn More

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