IAP

Catalog No.Inhibitor Name cIAPXIAPOther
A12738Birinapant
****
**
A14135GDC-0152
***
***
MLXBIR3SG
A13055Embelin
*
5-LO,mPGES-1
A14231BV-6
A11928LCL161
A15800SM-164
****
****
A11163AT406 (SM-406)
****

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. AT-406 (SM-406, ARRY-334543)

    Catalog No. A11163
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    IAP inhibitor
    AT-406 is an orally bioavailable inhibitor of IAP family of proteins with potential apoptotic inducing and antineoplastic activity. AT-406 selectively inhibits the biological activity of IAP proteins, including X chromosome-linked IAP (XIAP), the cellular IAPs 1 (c-IAP1) and 2 (c-IAP2) and melanoma inhibitor of apoptosis protein (ML-IAP). Learn More
  2. LCL-161

    Catalog No. A11928
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    Antagonist of IAPs inhibitor
    LCL161 is an orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity. Learn More
  3. Birinapant (TL32711)

    Catalog No. A12738
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    XIAP/cIAP1 antagonist
    Birinapant, also known as TL32711, is a synthetic small molecule and peptido mimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity. Learn More
  4. GDC-0152

    Catalog No. A14135
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    IAP antagonist
    GDC-0152 is a second mitochondrial activator of caspases (Smac) mimetic inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity. Learn More
  5. BV-6

    Catalog No. A14231
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    dual cIAP and XIAP inhibitor
    BV-6 is a SMAC mimetic, dual cIAP and XIAP inhibitor. Learn More
  6. SM-164

    Catalog No. A15800
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    cIAP-2 antagonist
    SM-164 is a potent cell-permeable and bivalent Smac mimetic which bind to a XIAP protein with a Ki value of 0.56 nM, and binds to cIAP-1 and cIAP-2 proteins with Ki values of 0.31 and 1.1 nM, respectively. Learn More
  7. Embelin

    Catalog No. A13055
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    XIAP inhibitor
    Embelin is a cell-permeable benzoquinone compound that exhibits antitumor properties. Learn More
  8. Apoptosis Inhibitor (M50054)

    Catalog No. A13058
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    Apoptosis Inhibitor
    Apoptosis Inhibitor is a cell-permeable inhibitor of apoptosis induction. Learn More

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