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IAP

Inhibitory Selectivity
Catalog No.Inhibitor Name cIAPXIAPOther
A12738Birinapant
****
**
A14135GDC-0152
***
***
MLXBIR3SG
A13055Embelin
*
5-LO,mPGES-1
A14231BV-6
A11928LCL161
A15800SM-164
****
****
A11163AT406 (SM-406)
****

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A11163 SALE

AT-406 (SM-406, ARRY-334543)

IAP inhibitor
AT-406 is an orally bioavailable inhibitor of IAP family of proteins with potential apoptotic inducing and antineoplastic activity. AT-406 selectively inhibits the biological activity of IAP proteins, including X chromosome-linked IAP (XIAP), the cellular IAPs 1 (c-IAP1) and 2 (c-IAP2) and melanoma inhibitor of apoptosis protein (ML-IAP).
A11928 SALE

LCL-161

Antagonist of IAPs inhibitor
LCL161 is an orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity.
A12738 SALE

Birinapant (TL32711)

XIAP/cIAP1 antagonist
Birinapant, also known as TL32711, is a synthetic small molecule and peptido mimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity.
A14135 SALE

GDC-0152

IAP antagonist
GDC-0152 is a second mitochondrial activator of caspases (Smac) mimetic inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity.
A14231

BV-6

dual cIAP and XIAP inhibitor
BV-6 is a SMAC mimetic, dual cIAP and XIAP inhibitor.
A15800

SM-164

cIAP-2 antagonist
SM-164 is a potent cell-permeable and bivalent Smac mimetic which bind to a XIAP protein with a Ki value of 0.56 nM, and binds to cIAP-1 and cIAP-2 proteins with Ki values of 0.31 and 1.1 nM, respectively.
A13055

Embelin

XIAP inhibitor
Embelin is a cell-permeable benzoquinone compound that exhibits antitumor properties.
A13058

Apoptosis Inhibitor (M50054)

Apoptosis Inhibitor
Apoptosis Inhibitor is a cell-permeable inhibitor of apoptosis induction.

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