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| Catalog No. | Inhibitor Name | cIAP | XIAP | Other |
|---|---|---|---|---|
| A12738 | Birinapant | **** | ** | |
| A14135 | GDC-0152 | *** | *** | MLXBIR3SG |
| A13055 | Embelin | * | 5-LO,mPGES-1 | |
| A14231 | BV-6 | |||
| A11928 | LCL161 | |||
| A15800 | SM-164 | **** | **** | |
| A11163 | AT406 (SM-406) | **** |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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AT-406 (SM-406, ARRY-334543)
Catalog No. A11163 IAP inhibitorAT-406 is an orally bioavailable inhibitor of IAP family of proteins with potential apoptotic inducing and antineoplastic activity. AT-406 selectively inhibits the biological activity of IAP proteins, including X chromosome-linked IAP (XIAP), the cellular IAPs 1 (c-IAP1) and 2 (c-IAP2) and melanoma inhibitor of apoptosis protein (ML-IAP). Learn More -
LCL-161
Catalog No. A11928 Antagonist of IAPs inhibitorLCL161 is an orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity. Learn More -
BV-6
Catalog No. A14231 dual cIAP and XIAP inhibitorBV-6 is a SMAC mimetic, dual cIAP and XIAP inhibitor. Learn More -
SM-164
Catalog No. A15800 cIAP-2 antagonistSM-164 is a potent cell-permeable and bivalent Smac mimetic which bind to a XIAP protein with a Ki value of 0.56 nM, and binds to cIAP-1 and cIAP-2 proteins with Ki values of 0.31 and 1.1 nM, respectively. Learn More -
Birinapant (TL32711)
Catalog No. A12738 XIAP/cIAP1 antagonistBirinapant, also known as TL32711, is a synthetic small molecule and peptido mimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity. Learn More -
GDC-0152
Catalog No. A14135 IAP antagonistGDC-0152 is a second mitochondrial activator of caspases (Smac) mimetic inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity. Learn More -
Embelin
Catalog No. A13055 XIAP inhibitorEmbelin is a cell-permeable benzoquinone compound that exhibits antitumor properties. Learn More -
Apoptosis Inhibitor (M50054)
Catalog No. A13058 Apoptosis InhibitorApoptosis Inhibitor is a cell-permeable inhibitor of apoptosis induction. Learn More
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