IGF-1R

Catalog No.Inhibitor Name IGF-1RInsulin ReceptorOther
A11053Linsitinib
***
**
IRR
A11021NVP-AEW541
**
**
FLT3,Tek,FLT1
A10440GSK1904529A
***
***
IKK3,VEGFR2,Syk
A10658NVP-ADW742
*
A11054BMS-536924
**
***
FAK,MEK,LCK
A11400AG-1024
*
*
A11175GSK1838705A
***
****
ALK,RSK1,JNK3
A11059BMS-754807
****
****
TrkB,Met,TrkA
A11951PQ 401
*
A12195Picropodophyllin
****

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. NVP-AEW541

    Catalog No. A11021
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    IGF-1R inhibitor
    NVP-AEW541 is a selective IGF-1R kinase inhibitor that inhibits the autophosphorylation activity of IGF-1R (IC50 = 0.086 uM) and prevents IGF-1-mediated survival and proliferation of MCF-7 cells (IC50 = 0.16 and 1.64 uM, respectively). Learn More
  2. XL-228

    Catalog No. A13069
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    IGF-1R, Aurora, FGFR, ABL, SRC inhibitor
    XL228 is a protein kinase inhibitor targeting IGF1R, the AURORA kinases, FGFR1-3, ABL and SRC family kinases. XL228 is an Aurora A inhibitor (IC50, f3 nmol/L) that has shown potent biochemical activity against ABL1 (Ki, 5 nmol/L), as well as the BCR-ABL1 T315I (Ki, 1.4 nmol/L) kinases. Learn More
  3. Picropodophyllin

    Catalog No. A12195
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    Picropodophyllin (AXL1717) is the first targeted oral small-molecule IGF-1 receptor inhibitor with no effect on the insulin receptor. Learn More
  4. PQ 401

    Catalog No. A11951
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    IGF-1R inhibitor
    PQ 401 is a cell-permeable phenylquinolinyl-urea compound that inhibits IGF-1R autophosphorylation. Learn More
  5. NVP-ADW742

    Catalog No. A10658
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    IGF-1R inhibitor
    NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM. Learn More
  6. GSK1838705A

    Catalog No. A11175
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    IGF-1R Inhibitor

    GSK1838705A is a small-molecule kinase inhibitor that inhibits IGF-IR and the insulin receptor with IC50s of 2.0 and 1.6 nmol/L, respectively.

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  7. AG-1024 (Tyrphostin)

    Catalog No. A11400
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    IGF-1R Inhibitor
    AG-1024 (Tyrphostin) is a specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kinase activity. Exhibits lower IC50 values for IGF-1 than for the insulin receptor. Also inhibits insulin-stimulated cellular proliferation. Learn More
  8. GSK1904529A

    Catalog No. A10440
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    IGF-1R inhibitor
    GSK1904529A selectively inhibits IGF-IR and IR with IC(50)s of 27 and 25 nmol/L, respectively. Learn More
  9. BMS-754807

    Catalog No. A11059
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    IGF-1R inhibitor
    BMS-754807 is an efficacious, orally active growth factor 1 receptor/insulin receptor family-targeted kinase inhibitor that may act in combination with a wide array of established anticancer agents. Learn More
  10. BMS-536924

    Catalog No. A11054
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    IGF-1R inhibitor
    BMS-536924 is an effective inhibitor of IGF-IR, causing a reversion of an IGF-IR - mediated transformed phenotype. Learn More
  11. OSI-906

    Catalog No. A11053
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    IGF-1R inhibitor
    OSI-906 is a potential first-in-class selective small molecule, dual kinase inhibitor of both insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR). Learn More
  12. NT157

    Catalog No. A16247
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    IRS-1/2 inhibitor
    NT157 is a selective inhibitor of IRS-1/2. Learn More

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