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| Catalog No. | Inhibitor Name | IGF-1R | Insulin Receptor | Other |
|---|---|---|---|---|
| A11053 | Linsitinib | *** | ** | IRR |
| A11021 | NVP-AEW541 | ** | ** | FLT3,Tek,FLT1 |
| A10440 | GSK1904529A | *** | *** | IKK3,VEGFR2,Syk |
| A10658 | NVP-ADW742 | * | ||
| A11054 | BMS-536924 | ** | *** | FAK,MEK,LCK |
| A11400 | AG-1024 | * | * | |
| A11175 | GSK1838705A | *** | **** | ALK,RSK1,JNK3 |
| A11059 | BMS-754807 | **** | **** | TrkB,Met,TrkA |
| A11951 | PQ 401 | * | ||
| A12195 | Picropodophyllin | **** |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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NVP-AEW541
Catalog No. A11021 IGF-1R inhibitorNVP-AEW541 is a selective IGF-1R kinase inhibitor that inhibits the autophosphorylation activity of IGF-1R (IC50 = 0.086 uM) and prevents IGF-1-mediated survival and proliferation of MCF-7 cells (IC50 = 0.16 and 1.64 uM, respectively). Learn More -
OSI-906
Catalog No. A11053 IGF-1R inhibitorOSI-906 is a potential first-in-class selective small molecule, dual kinase inhibitor of both insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR). Learn More -
BMS-754807
Catalog No. A11059 IGF-1R inhibitorBMS-754807 is an efficacious, orally active growth factor 1 receptor/insulin receptor family-targeted kinase inhibitor that may act in combination with a wide array of established anticancer agents. Learn More -
AG-1024 (Tyrphostin)
Catalog No. A11400 IGF-1R InhibitorAG-1024 (Tyrphostin) is a specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kinase activity. Exhibits lower IC50 values for IGF-1 than for the insulin receptor. Also inhibits insulin-stimulated cellular proliferation. Learn More -
GSK1838705A
Catalog No. A11175 IGF-1R InhibitorGSK1838705A is a small-molecule kinase inhibitor that inhibits IGF-IR and the insulin receptor with IC50s of 2.0 and 1.6 nmol/L, respectively.
Learn More -
NVP-ADW742
Catalog No. A10658 IGF-1R inhibitorNVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM. Learn More -
Indirubin Derivative E804
Catalog No. A21052 IGF1R inhibitorE 804 is a potent inhibitor of Insulin-like Growth Factor 1 Receptor (IGF1R), with an IC50 of 0.65 μM for IGF1R. Learn More -
BMS-536924
Catalog No. A11054 IGF-1R inhibitorBMS-536924 is an effective inhibitor of IGF-IR, causing a reversion of an IGF-IR - mediated transformed phenotype. Learn More -
GSK1904529A
Catalog No. A10440 IGF-1R inhibitorGSK1904529A selectively inhibits IGF-IR and IR with IC(50)s of 27 and 25 nmol/L, respectively. Learn More -
PQ 401
Catalog No. A11951 IGF-1R inhibitorPQ 401 is a cell-permeable phenylquinolinyl-urea compound that inhibits IGF-1R autophosphorylation. Learn More -
Picropodophyllin
Catalog No. A12195 Picropodophyllin (AXL1717) is the first targeted oral small-molecule IGF-1 receptor inhibitor with no effect on the insulin receptor. Learn More -
XL-228
Catalog No. A13069 IGF-1R, Aurora, FGFR, ABL, SRC inhibitorXL228 is a protein kinase inhibitor targeting IGF1R, the AURORA kinases, FGFR1-3, ABL and SRC family kinases. XL228 is an Aurora A inhibitor (IC50, f3 nmol/L) that has shown potent biochemical activity against ABL1 (Ki, 5 nmol/L), as well as the BCR-ABL1 T315I (Ki, 1.4 nmol/L) kinases. Learn More -
AZD3463
Catalog No. A13065 -
NT157
Catalog No. A16247
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