Catalog No.
Product Name
Application
Product Information
Product Citation
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Pdia3/ERp57 activator, STAT3 inhibitor
Diosgenin glucoside, a saponin compound extracted from Tritulus terrestris L., provides neuroprotection by regulating microglial M1 polarization. Diosgenin glucoside protects against spinal cord injury by regulating autophagy and alleviating apoptosis . - Ingenol mebutate is a substance found in the sap of the plant Euphorbia peplus and an inducer of cell death.
- Yao-Yu Hsieh, .et al. , Toxicol Appl Pharmacol, 2022, Aug 15;449 PMID: 35724704
- Coumarin 30 is useful as laser dye. Efficient laser dye for pulsed and CW operation.
- Armillarisin A is a regulator and promotor of immune functions. It acts by enhancing the role of macrophages, inhibiting bacteria growth, improving the protein metabolism, and regulating liver function.
- Ligustilide, a main lipophilic component of Danggui (Chinese Angelica root, Radix Angelica sinensis), alleviates brain damage and improves cognitive function in rats of chronic cerebral hypoperfusion.
- Chin-Yi Cheng, .et al. , J Ethnopharmacol, 2021, Jun 4;278:114301 PMID: 34090910
- Yu-Chen Lee, .et al. , Research Square, 2020, Sep 17
- Puromycin Aminonucleoside is an aminonucleoside antibiotic that blocks protein synthesis in both prokaryotes and eukaryotes by causing premature termination of nascent polypeptide chains.
- Sauristolactam, a natural aristolactam isolated from aerial portions of Saururus chinensis, has significant neuroprotective activity against glutamate-induced toxicity in primary cultured rat cortical cells.
- Harringtonin is an alkaloid isolated from Cephalotaxus harringtonia, and an antitumor agent.
- Cyclosporin C is a highly lipophilic cyclic peptide natural product, a member of the cyclosporin series of antifungal and immunosuppresive compounds - Cyclosporin A and B. The cyclosporins bind the cyclophilin intracellular proteins, highly conserved proteins involved in cis-trans isomerization of peptidyl-prolyl bonds and protein folding.
- Hygromycin B is an aminoglycoside antibiotic isolated from Streptomyces hygroscopicus. It acts by inhibiting protein synthesis by inducing the misreading of the m-RNA template in the prokaryote, with the potency to inhibit translation.
- Silibinin has also demonstrated in vitro anti-cancer effects against human prostate adenocarcinoma cells, estrogen-dependent and -independent human breast carcinoma cells, human ectocervical carcinoma cells, human colon cancer cells, and both small and nonsmall human lung carcinoma cells.
- Meisoindigo, a derivative of Indigo naturalis, is a promising agent with in vitro and in vivo activity against human acute myeloid leukemia.
- Dynemicin A is an antitumor natural product isolated from Micromonospora chersina which causes DNA strand cleavage.
- Chowdhury N, .et al. , Biotechnol Bioeng, 2016, Sep;113(9):1984-92 PMID: 26914280
- Proscillaridin A is a cardiac glycoside first isolated from plants in the genus Scilla.
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Proteasome Inhibitor
Marizomib is a naturally-occurring salinosporamide, isolated from the marine actinomycete Salinospora tropica, with potential antineoplastic activity.- Tarantelli C, .et al. , Clin Cancer Res, 2018, Jan 1;24(1):120-129 PMID: 29066507
- Wiskostatin is a cell-permeable N-alkylated carbazole derivative that selectively blocks actin filament assembly. The compound acts as a selective, reversible inhibitor of N-WASP (neural Wiskott Aldrich syndrome protein), a signal integrating protein. Wiskostatin also binds to N-WASP, stabilize the autoinhibited conformation and prevent the activation of Arp2/3 (actin-related protein 2/3) complex.
- Trichodesmine is a pyrrolizidine alkaloid that has neurotoxic effects and is naturally found in Crotolaria argyptiaca, a shrub plant that is native to the south eastern desert of Egypt.
- Rashmi Rawat, .et al. , Food Chemistry Advances, 2022, 1: 100092
- Nitrarine 2HCl is a hypotensive? spasmolytic? coronary dilator? sedative in experimental arrhythmias. in experimental arrhythmias in the cat? caused by calcium chloride? Aconitine and electric cardiac stimulation? Nitrarine dihydrochloride presents a hypotensive? spasmolytic? coronary dilating and sedative action. Its antiarrhythmic properties are due to its stabilizating effects on the membrane and its coronary dilating action. Nitrarine dihydrochloride is 3-4 times as potent as Novocainamide and Quinidine? and the duration of its effect is 2-5 times longer than that of these products.
- Lycoctonine is a plant alkaloid and a precursor to the ABC ring system of taxoids.
- 20-Hydroxyecdysone is an ecdysteroid hormone produced in arthropod species that induces developmental changes associated with ecdysis and the completion of metamorphosis.
- Chunyan Fang, .et al. , Development, 2022, Jan 15;149(2):dev199841 PMID: 35088829
- Miwako Toyofuku, .et al. , J Insect Physiol, 2021, Oct;134:104294 PMID: 34389412
- Fraxinellone is an insecticidal agent, inhibiting growth of larvae, used in the treatment and protection of crops and produce. Also, a naturally occurring compound used in the treatment of tumors.
- Diacetylkorseveriline is an antiarrhythmic (classes i and iv)? belonging to a novel structural class. effective against arrhythmia caused by aconitine? cacl2? electric stimulation of the ventricles or ligature of the aorta, recommended dose for one cycle of experiment on mice: 3.0-30.0 mg/kg? intravenously.
- Betonicine can be found in herbs and spices and pulses, which makes betonicine a potential biomarker for the consumption of these food products. Betonicine can be found primarily in urine. This compound belongs to the class of organic compounds known as l-alpha-amino acids.
- Hederagenin, a triterpenoid saponin, is used to study the properties of triterpenoid saponins as biopesticides that prevent fungal growth, bacterial growth, and viral plant diseases.
- Harpagoside is an anti-inflammatory small molecule natural product originally isolated from the Harpagophytum procumbens (Devil??s Claw) root, but can be isolated from other plants such as Crophularia ningpoensis Hemsl (Figwort).
- Mitragynine is an indole alkaloid from the plant Mitragyna speciosa. It has stimulatory, antinociceptive, and opiate-like effects, acting through noradrenergic, serotonergic, and opioid receptors
- Desacetylnimbin is a new limonoid from Arisaema decipiens, a traditional antitumor herb.
- Triacsin C, originally isolated from Streptomyces sp., is an inhibitor of long fatty acid acyl-CoA synthetase (IC50 = 6.3 uM in Raji cells).
- Protostemonine (PSN) is the main anti-inflammatory alkaloid extracted from the roots of Stemona sessilifolia (known as ?€?Baibu?€? in traditional Chinese medicine).
- 8-Gingerol is a bioactive ingredient of ginger (Zingiber officinale) having anti-nausea, anti-inflammatory, and anti-carcinogenic properties.
- Mesaconitine is one of the Aconitum sp. alkaloids, compounds that exist in an extensive variety of plant species.
- Typhaneoside is found in ginkgo nuts.
- Kuan-Ming Chiu, .et al. , Chem Res Toxicol, 2021, May 17;34(5):1286-1295 PMID: 33621091
- Cinnamaldehyde is the organic compound that gives cinnamon its flavor and odor.
- Cinnamyl alcohol is an organic compound that is found in esterified form in storax, Balsam of Peru, and cinnamon leaves.
- Ophiopogonin D is a new phenylpropanoid glycoside from Ophiopogon japonicus Ker-Gawl.